In silico binding analysis and SAR elucidations of newly designed benzopyrazine analogs as potent inhibitors of thymidine phosphorylase
Thymidine phosphorylase (TP) is up regulated in wide variety of solid tumors and therefore presents a remarkable target for drug discovery in cancer. A novel class of extremely potent TPase inhibitors based on benzopyrazine (1–28) has been developed and evaluated against thymidine phosphorylase enzy...
| Published in: | Bioorganic Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Academic Press Inc.
2016
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979619091&doi=10.1016%2fj.bioorg.2016.07.010&partnerID=40&md5=40ed2677dc1df64b71178e6fc7babcd0 |