Synthesis of novel disulfide and sulfone hybrid scaffolds as potent β-glucuronidase inhibitor

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Synthesis of novel disulfide and sulfone hybrid scaffolds as potent β-glucuronidase inhibitor

Novel series of disulfide and sulfone hybrid analogs (1 −2 0) were synthesized and characterized through EI-MS and 1H NMR and evaluated for β-glucuronidase inhibitory potential. All synthesized analogs except 13 and 15 showed excellent β-glucuronidase inhibitory potential with IC50 value ranging in...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Al Muqarrabin L.M.R.; Zaki H.M.; Ahmat N.; Nasir A.; Khan F.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978792041&doi=10.1016%2fj.bioorg.2016.07.002&partnerID=40&md5=fab601fd5abd5eb3632e5e695647f875

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