Novel thiosemicarbazide-oxadiazole hybrids as unprecedented inhibitors of yeast α-glucosidase and in silico binding analysis

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Novel thiosemicarbazide-oxadiazole hybrids as unprecedented inhibitors of yeast α-glucosidase and in silico binding analysis

Compounds 1-18, new oxadiazole-thiosemicarbazide hybrids, were synthesized using a five-step reaction sequence in excellent yields. All the synthesized analogs exhibited exceptional α-glucosidase inhibitory potentials in the range of 0.4-38.1 μM. Among the current series, it was observed that the fl...

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Bibliographic Details
Published in:	RSC Advances
Main Author:	Taha M.; Ismail N.H.; Imran S.; Wadood A.; Ali M.; Rahim F.; Khan A.A.; Riaz M.
Format:	Article
Language:	English
Published:	Royal Society of Chemistry 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964523904&doi=10.1039%2fc5ra28012e&partnerID=40&md5=aa6dbb8465ae9ee063c8c7663e2f2783

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