Coupling genotyping and computational modeling in prediction of antiepileptic drugs that cause Stevens Johnson syndrome and toxic epidermal Necrolysis for carrier of HLA-B*15:02

Coupling genotyping and computational modeling in prediction of antiepileptic drugs that cause Stevens Johnson syndrome and toxic epidermal Necrolysis for carrier of HLA-B*15:02

Purpose. The importance of HLA-B*15:02 genotyping to avoid carbamazepine induced SJS/TEN and molecular modeling to predict the role of HLA-B*15:0 and AEDs induced SJS/TEN are investigated. Methods. DNA was extracted from eighty-six patients. The patients were genotyped by AS-PCR. Computational model...

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Bibliographic Details
Published in:Journal of Pharmacy and Pharmaceutical Sciences
Main Author: Teh L.K.; Selvaraj M.; Bannur Z.; Ismail M.I.M.; Rafia M.H.; Law W.C.; Sapuan S.; Puvanarajah S.; Ali P.S.S.; Salleh M.Z.
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2016
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961762798&doi=10.18433%2fJ38G7X&partnerID=40&md5=0aa9ba3460c8df8691191864ad1bf729

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961762798&doi=10.18433%2fJ38G7X&partnerID=40&md5=0aa9ba3460c8df8691191864ad1bf729

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