Synthesis, α-glucosidase inhibitory, cytotoxicity and docking studies of 2-aryl-7-methylbenzimidazoles
Benzimidazole analogs 1-27 were synthesized, characterized by EI-MS and 1H NMR and their α-glucosidase inhibitory activities were found out experimentally. Compound 25, 19, 10 and 20 have best inhibitory activities with IC50 values 5.30 ± 0.10, 16.10 ± 0.10, 25.36 ± 0.14 and 29.75 ± 0.19 respectivel...
| Published in: | Bioorganic Chemistry |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Academic Press Inc.
2016
|
| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959018778&doi=10.1016%2fj.bioorg.2016.02.004&partnerID=40&md5=f00e8b96e7b75766ee1842b5b42fdfa3 |