Identification of bisindolylmethane-hydrazone hybrids as novel inhibitors of β-glucuronidase, DFT, and in silico SAR intimations

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Identification of bisindolylmethane-hydrazone hybrids as novel inhibitors of β-glucuronidase, DFT, and in silico SAR intimations

The present study involves the synthesis of bisindolylmethane-hydrazone hybrids, 1-30, in a three-step reaction sequence, followed by evaluation against β-glucuronidase enzyme. The IC50 values for the potent compounds were in the range from 0.10 to 83.50 μM. Compound, a trihydroxy analog was found t...

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Bibliographic Details
Published in:	RSC Advances
Main Author:	Taha M.; Ismail N.H.; Imran S.; Anouar E.H.; Ali M.; Jamil W.; Uddin N.; Kashif S.M.
Format:	Article
Language:	English
Published:	Royal Society of Chemistry 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954148937&doi=10.1039%2fc5ra19513f&partnerID=40&md5=49d79b871596792e0ca826baf1620051

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