Identification of bisindolylmethane-hydrazone hybrids as novel inhibitors of β-glucuronidase, DFT, and in silico SAR intimations
The present study involves the synthesis of bisindolylmethane-hydrazone hybrids, 1-30, in a three-step reaction sequence, followed by evaluation against β-glucuronidase enzyme. The IC50 values for the potent compounds were in the range from 0.10 to 83.50 μM. Compound, a trihydroxy analog was found t...
| Published in: | RSC Advances |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2016
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954148937&doi=10.1039%2fc5ra19513f&partnerID=40&md5=49d79b871596792e0ca826baf1620051 |