Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies

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Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies

Disulfide analogs (1-20) have been synthesized, characterized by HR-MS,1H NMR and13C NMR and screened for urease inhibitory potential. All compounds were found to have varied degree of urease inhibitory potential ranging in between 0.4 ± 0.01 and 18.60 ± 1.24 μM when compared with standard inhibitor...

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Riaz M.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2015
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946228073&doi=10.1016%2fj.bmc.2015.10.017&partnerID=40&md5=e220546463e982308f98d0ae9ede33ff

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