Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of α-glucosidases

Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of α-glucosidases

Biscoumarin analogs 1-18 have been synthesized, characterized by EI-MS and 1H NMR and evaluated for α-glucosidase inhibitory potential. All compounds showed variety of α-glucosidase inhibitory potential ranging in between 13.5 ± 0.39 and 104.62 ± 0.3 μM when compared with standard acarbose having IC...

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Bibliographic Details
Published in:Bioorganic Chemistry
Main Author: Zawawi N.K.N.A.; Taha M.; Ahmat N.; Ismail N.H.; Wadood A.; Rahim F.; Rehman A.U.
Format: Article
Language:English
Published: Academic Press Inc. 2015
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942945274&doi=10.1016%2fj.bioorg.2015.09.004&partnerID=40&md5=550982f9b5743c78d8ad9a3e07dd6408

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942945274&doi=10.1016%2fj.bioorg.2015.09.004&partnerID=40&md5=550982f9b5743c78d8ad9a3e07dd6408

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