Triazinoindole analogs as potent inhibitors of α-glucosidase: Synthesis, biological evaluation and molecular docking studies

Triazinoindole analogs as potent inhibitors of α-glucosidase: Synthesis, biological evaluation and molecular docking studies

A new series of triazinoindole analogs 1-11 were synthesized, characterized by EI-MS and 1H NMR, evaluated for α-glucosidase inhibitory potential. All eleven (11) analogs showed different range of α-glucosidase inhibitory potential with IC50 value ranging between 2.46 ± 0.008 and 312.79 ± 0.06 μM wh...

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Bibliographic Details
Published in:Bioorganic Chemistry
Main Author: Rahim F.; Ullah K.; Ullah H.; Wadood A.; Taha M.; Rehman A.U.; Uddin I.; Ashraf M.; Shaukat A.; Rehman W.; Hussain S.; Khan K.M.
Format: Article
Language:English
Published: Academic Press Inc. 2015
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919941245&doi=10.1016%2fj.bioorg.2014.12.001&partnerID=40&md5=79a338ff4fb9911bebc292bf68f10017

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919941245&doi=10.1016%2fj.bioorg.2014.12.001&partnerID=40&md5=79a338ff4fb9911bebc292bf68f10017

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