Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities

Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities

4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 μM, better than standard drug rutin (294.46 ± 1.50 μM). Compound 1-28 were also evaluated for DPPH activitie...

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Published in:European Journal of Medicinal Chemistry
Main Author: Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
Format: Article
Language:English
Published: Elsevier Masson SAS 2014
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905161829&doi=10.1016%2fj.ejmech.2014.07.078&partnerID=40&md5=bf97c4e0f2f2d9107b8b4ff76f9ebc45
id 2-s2.0-84905161829
spelling 2-s2.0-84905161829
Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
2014
European Journal of Medicinal Chemistry
84

10.1016/j.ejmech.2014.07.078
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905161829&doi=10.1016%2fj.ejmech.2014.07.078&partnerID=40&md5=bf97c4e0f2f2d9107b8b4ff76f9ebc45
4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 μM, better than standard drug rutin (294.46 ± 1.50 μM). Compound 1-28 were also evaluated for DPPH activities. Compounds 1-8 showed excellent activities, ranging 12-29 μM, better than standard drug n-propylgallate (IC50 = 30.30 ± 0.40 μM). For superoxide anion scavenging activity, compounds 1-7 showed better activity than standard n-propylgallate (IC50 = 106.34 ± 1.6 μM), ranged 82-104 μM. These compounds were found to be nontoxic to THP-1 cells. © 2014 Elsevier Masson SAS. All rights reserved.
Elsevier Masson SAS
2235234
English
Article
author Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
spellingShingle Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
author_facet Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
author_sort Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
title Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
title_short Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
title_full Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
title_fullStr Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
title_full_unstemmed Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
title_sort Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
publishDate 2014
container_title European Journal of Medicinal Chemistry
container_volume 84
container_issue
doi_str_mv 10.1016/j.ejmech.2014.07.078
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905161829&doi=10.1016%2fj.ejmech.2014.07.078&partnerID=40&md5=bf97c4e0f2f2d9107b8b4ff76f9ebc45
description 4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 μM, better than standard drug rutin (294.46 ± 1.50 μM). Compound 1-28 were also evaluated for DPPH activities. Compounds 1-8 showed excellent activities, ranging 12-29 μM, better than standard drug n-propylgallate (IC50 = 30.30 ± 0.40 μM). For superoxide anion scavenging activity, compounds 1-7 showed better activity than standard n-propylgallate (IC50 = 106.34 ± 1.6 μM), ranged 82-104 μM. These compounds were found to be nontoxic to THP-1 cells. © 2014 Elsevier Masson SAS. All rights reserved.
publisher Elsevier Masson SAS
issn 2235234
language English
format Article
accesstype
record_format scopus
collection Scopus
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