Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 μM, better than standard drug rutin (294.46 ± 1.50 μM). Compound 1-28 were also evaluated for DPPH activitie...
| Published in: | European Journal of Medicinal Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier Masson SAS
2014
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905161829&doi=10.1016%2fj.ejmech.2014.07.078&partnerID=40&md5=bf97c4e0f2f2d9107b8b4ff76f9ebc45 |
| Summary: | 4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 μM, better than standard drug rutin (294.46 ± 1.50 μM). Compound 1-28 were also evaluated for DPPH activities. Compounds 1-8 showed excellent activities, ranging 12-29 μM, better than standard drug n-propylgallate (IC50 = 30.30 ± 0.40 μM). For superoxide anion scavenging activity, compounds 1-7 showed better activity than standard n-propylgallate (IC50 = 106.34 ± 1.6 μM), ranged 82-104 μM. These compounds were found to be nontoxic to THP-1 cells. © 2014 Elsevier Masson SAS. All rights reserved. |
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| ISSN: | 2235234 |
| DOI: | 10.1016/j.ejmech.2014.07.078 |