Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease

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Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease

A series of thiobarbituric acid derivatives 1-27 were synthesized and evaluated for their urease inhibitory potential. Exciting results were obtained from the screening of these compounds 1-27. Compounds 5, 7, 8, 11, 16, 17, 22, 23 and 24 showed excellent urease inhibition with IC50 values 18.1 ± 0....

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Khan K.M.; Rahim F.; Khan A.; Shabeer M.; Hussain S.; Rehman W.; Taha M.; Khan M.; Perveen S.; Choudhary M.I.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2014
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905087111&doi=10.1016%2fj.bmc.2014.05.057&partnerID=40&md5=0ac133b6b9d2f607886639bbe8fe0e0d

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