Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease
A series of thiobarbituric acid derivatives 1-27 were synthesized and evaluated for their urease inhibitory potential. Exciting results were obtained from the screening of these compounds 1-27. Compounds 5, 7, 8, 11, 16, 17, 22, 23 and 24 showed excellent urease inhibition with IC50 values 18.1 ± 0....
| Published in: | Bioorganic and Medicinal Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2014
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905087111&doi=10.1016%2fj.bmc.2014.05.057&partnerID=40&md5=0ac133b6b9d2f607886639bbe8fe0e0d |