Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones

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Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones

2-Arylquinazolin-4(3H)-ones 1-25 were synthesized by reacting anthranilamide with various benzaldehydes using CuCl2·2H 2O as a catalyst in ethanol under reflux. Synthetic 2-arylquinazolin-4(3H)-ones 1-25 were evaluated for their β-glucuronidase inhibitory potential. A trend of inhibition IC50 agains...

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Khan K.M.; Saad S.M.; Shaikh N.N.; Hussain S.; Fakhri M.I.; Perveen S.; Taha M.; Choudhary M.I.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2014
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901927895&doi=10.1016%2fj.bmc.2014.04.039&partnerID=40&md5=0e2ea5b060a41cd08faa053639f44ecd

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