Evaluation of bisindole as potent β-glucuronidase inhibitors: Synthesis and in silico based studies
Bisindole analogs 1-17 were synthesized and evaluated for their in vitro β-glucuronidase inhibitory potential. Out of seventeen compounds, the analog 1 (IC50 = 1.62 ± 0.04 μM), 6 (IC50 = 1.86 ± 0.05 μM), 10 (IC50 = 2.80 ± 0.29 μM), 9 (IC50 = 3.10 ± 0.28 μM), 14 (IC50 = 4.30 ± 0.08 μM), 2 (IC50 = 18....
| Published in: | Bioorganic and Medicinal Chemistry Letters |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2014
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897370463&doi=10.1016%2fj.bmcl.2014.02.015&partnerID=40&md5=2dabf22e5b34452708bb8e78f6af9300 |