Conserved gating elements in TRPC4 and TRPC5 channels

Conserved gating elements in TRPC4 and TRPC5 channels

TRPC4 and TRPC5 proteins share 65% amino acid sequence identity and form Ca2+-permeable nonselective cation channels. They are activated by stimulation of receptors coupled to the phosphoinositide signaling cascade. Replacing a conserved glycine residue within the cytosolic S4-S5 linker of both prot...

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Bibliographic Details
Published in:Journal of Biological Chemistry
Main Author: Beck A.; Speicher T.; Stoerger C.; Sell T.; Dettmer V.; Jusoh S.A.; Abdulmughni A.; Cavalié A.; Philipp S.E.; Zhu M.X.; Helms V.; Wissenbach U.; Flockerzi V.
Format: Article
Language:English
Published: 2013
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880072077&doi=10.1074%2fjbc.M113.478305&partnerID=40&md5=b8fe7638c740d78199aa4a03e1cd0988

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880072077&doi=10.1074%2fjbc.M113.478305&partnerID=40&md5=b8fe7638c740d78199aa4a03e1cd0988

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