Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives

Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives

N,N'-dimethylbarbituric acid derivatives 1-24 were evaluated for their xanthine oxidase (XO) inhibitory activity. Majority of these compounds showed a good to moderate in vitro xanthine oxidase inhibitory activity (IC50 = 20.97 ± 0.29 - 327.0 ± 3.50 μM), while eight compounds were found to be c...

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Published in:Journal of the Chemical Society of Pakistan
Main Author: Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
Format: Article
Language:English
Published: 2013
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878442900&partnerID=40&md5=bd50d12cd8fdab702c37c4bed5b59c8f
id 2-s2.0-84878442900
spelling 2-s2.0-84878442900
Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
2013
Journal of the Chemical Society of Pakistan
35
2

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878442900&partnerID=40&md5=bd50d12cd8fdab702c37c4bed5b59c8f
N,N'-dimethylbarbituric acid derivatives 1-24 were evaluated for their xanthine oxidase (XO) inhibitory activity. Majority of these compounds showed a good to moderate in vitro xanthine oxidase inhibitory activity (IC50 = 20.97 ± 0.29 - 327.0 ± 3.50 μM), while eight compounds were found to be completely inactive. A structure-activity relationship has been discussed, identifying structural features, responsible for varying degree of activity.

2535106
English
Article
author Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
spellingShingle Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
author_facet Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
author_sort Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
title Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
title_short Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
title_full Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
title_fullStr Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
title_full_unstemmed Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
title_sort Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
publishDate 2013
container_title Journal of the Chemical Society of Pakistan
container_volume 35
container_issue 2
doi_str_mv
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878442900&partnerID=40&md5=bd50d12cd8fdab702c37c4bed5b59c8f
description N,N'-dimethylbarbituric acid derivatives 1-24 were evaluated for their xanthine oxidase (XO) inhibitory activity. Majority of these compounds showed a good to moderate in vitro xanthine oxidase inhibitory activity (IC50 = 20.97 ± 0.29 - 327.0 ± 3.50 μM), while eight compounds were found to be completely inactive. A structure-activity relationship has been discussed, identifying structural features, responsible for varying degree of activity.
publisher
issn 2535106
language English
format Article
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record_format scopus
collection Scopus
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