Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility

The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106/mL of semen. Granular leukocytes when activated are capable of generating high levels of reactive oxygen species in semen resulting in oxidativ...

詳細記述

書誌詳細
出版年:World Journal of Men's Health
第一著者: Sharma R.; Gupta S.; Agarwal A.; Henkel R.; Finelli R.; Parekh N.; Saleh R.; Arafa M.; Ko E.; Zini A.; Tadros N.; Shah R.; Ambar R.F.; Elbardisi H.; Sengupta P.; Martinez M.; Boitrelle F.; Simopoulou M.; Vogiatzi P.; Gosalvez J.; Kavoussi P.; Kandil H.; Palani A.; Peña M.R.; Rajmil O.; Busetto G.M.; Anagnostopoulou C.; Micic S.; Alves M.G.; Rocco L.; Mostafa T.; Alvarez J.G.; Jindal S.; Sallam H.N.; Rosas I.M.; Lewis S.E.M.; AlSaid S.; Altan M.; Park H.J.; Ramsay J.; Parekattil S.; Sabbaghian M.; Tremellen K.; Khalafalla K.; Durairajanayagam D.; Colpi G.M.
フォーマット: 論文
言語:English
出版事項: Korean Society for Sexual Medicine and Andrology 2021
オンライン・アクセス:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109488169&doi=10.5534%2fWJMH.210063&partnerID=40&md5=bacb81539baaec8808c71dee9658a4d7
その他の書誌記述
要約:The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106/mL of semen. Granular leukocytes when activated are capable of generating high levels of reactive oxygen species in semen resulting in oxidative stress. Oxidative stress has been correlated with poor sperm quality, increased level of sperm DNA fragmentation and low fertility potential. The presence of leukocytes and pathogens in the semen may be a sign of infection and/or localized inflammatory response in the male genital tract and the accessory glands. Common uro-pathogens including Chlamydia trachomatis, Ureaplasma urealyticum, Neisseria gonorrhoeae, Mycoplasma hominis, and Escherichia coli can cause epididymitis, epididymo-orchitis, or prostatitis. The relationship between leukocytospermia and infection is unclear. Therefore, we describe the pathogens responsible for male genital tract infections and their association with leukocytospermia. The review also examines the diagnostic tests available to identify seminal leukocytes. The role of leukocytospermia in male infertility and its management is also discussed. © 2021 Korean Society for Sexual Medicine and Andrology. All rights reserved.
ISSN:22874208
DOI:10.5534/WJMH.210063