Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies
Newly synthesized benzimidazole hydrazone derivatives 1-26 were evaluated for their α-glucosidase inhibitory activity. Compounds 1-26 exhibited varying degrees of yeast α-glucosidase inhibitory activity with IC50 values between 8.40 ± 0.76 and 179.71 ± 1.11 μM when compared with standard acarbose. I...
| Published in: | Bioorganic Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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Academic Press Inc.
2016
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948649641&doi=10.1016%2fj.bioorg.2015.11.006&partnerID=40&md5=93ec464c2d71e54bbd8588cac5d567e0 |
| id |
Zawawi N.K.N.A.; Taha M.; Ahmat N.; Wadood A.; Ismail N.H.; Rahim F.; Azam S.S.; Abdullah N. |
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| spelling |
Zawawi N.K.N.A.; Taha M.; Ahmat N.; Wadood A.; Ismail N.H.; Rahim F.; Azam S.S.; Abdullah N. 2-s2.0-84948649641 Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies 2016 Bioorganic Chemistry 64 10.1016/j.bioorg.2015.11.006 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948649641&doi=10.1016%2fj.bioorg.2015.11.006&partnerID=40&md5=93ec464c2d71e54bbd8588cac5d567e0 Newly synthesized benzimidazole hydrazone derivatives 1-26 were evaluated for their α-glucosidase inhibitory activity. Compounds 1-26 exhibited varying degrees of yeast α-glucosidase inhibitory activity with IC50 values between 8.40 ± 0.76 and 179.71 ± 1.11 μM when compared with standard acarbose. In this assay, seven compounds that showed highest inhibitory effects than the rest of benzimidazole series were identified. All the synthesized compounds were characterized by different spectroscopic methods adequately. We further evaluated the interaction of the active compounds with enzyme with the help of docking studies. © 2015 Elsevier Inc. All rights reserved. Academic Press Inc. 452068 English Article |
| author |
2-s2.0-84948649641 |
| spellingShingle |
2-s2.0-84948649641 Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies |
| author_facet |
2-s2.0-84948649641 |
| author_sort |
2-s2.0-84948649641 |
| title |
Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies |
| title_short |
Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies |
| title_full |
Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies |
| title_fullStr |
Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies |
| title_full_unstemmed |
Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies |
| title_sort |
Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies |
| publishDate |
2016 |
| container_title |
Bioorganic Chemistry |
| container_volume |
64 |
| container_issue |
|
| doi_str_mv |
10.1016/j.bioorg.2015.11.006 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948649641&doi=10.1016%2fj.bioorg.2015.11.006&partnerID=40&md5=93ec464c2d71e54bbd8588cac5d567e0 |
| description |
Newly synthesized benzimidazole hydrazone derivatives 1-26 were evaluated for their α-glucosidase inhibitory activity. Compounds 1-26 exhibited varying degrees of yeast α-glucosidase inhibitory activity with IC50 values between 8.40 ± 0.76 and 179.71 ± 1.11 μM when compared with standard acarbose. In this assay, seven compounds that showed highest inhibitory effects than the rest of benzimidazole series were identified. All the synthesized compounds were characterized by different spectroscopic methods adequately. We further evaluated the interaction of the active compounds with enzyme with the help of docking studies. © 2015 Elsevier Inc. All rights reserved. |
| publisher |
Academic Press Inc. |
| issn |
452068 |
| language |
English |
| format |
Article |
| accesstype |
|
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1828987880375058432 |