Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3
Ternatin-family cyclic peptides inhibit protein synthesis by targeting the eukaryotic elongation factor-1α. A potentially related cytotoxic natural product (‘A3’) was isolated from Aspergillus, but only 4 of its 11 stereocentres could be assigned. Here, we synthesized SR-A3 and SS-A3—two out of 128...
| 發表在: | Nature Chemistry |
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| 主要作者: | |
| 格式: | Article |
| 語言: | English |
| 出版: |
Nature Research
2022
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| 在線閱讀: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138252320&doi=10.1038%2fs41557-022-01039-3&partnerID=40&md5=44c9a7f870825e1eb27788b958447242 |