Antimicrobial and antiviral effect of cellulose acetate nanofibres doped with pyrrolidone against methicillin-resistant Staphylococcus aureus (MRSA) and human coronavirus 229E (HCoV-229E)

• Published in: JOURNAL OF HAZARDOUS MATERIALS ADVANCES
• Main Authors: Salleh, Shahrul Nizam Md.; Abdullah, Mohamad Zaki; Saheed, Mohamed Shuaib Mohamed; Mohammat, Mohd Fazli
• Format: Article
• Language: English
• Published: ELSEVIER 2025
• Subjects: Engineering; Environmental Sciences & Ecology
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001409892800001
• ISSN: 2772-4166
• DOI: 10.1016/j.hazadv.2025.100598

The paper investigated the effectiveness of cellulose acetate (CA) nanofibres doped with a newly synthesized compound against MRSA microbe and HCoV-229E virus. MRSA microbe was responsible for antibiotic resistance diseases and HCoV-229E virus can cause mild to chronic respiratory tract infections. The pyrrolidone compound was synthesized using a one-pot sonochemistry technique and was chemically characterized followed by a toxicological assessment. Subsequently, it was dissolved in a tri-solvent solution containing cellulose acetate and electrospun to create the nanofibre membrane. The resulting membrane underwent characterization and testing against MRSA bacteria and HCoV-229E virus. The findings indicate that the nanofibre membrane, doped with the synthesized pyrrolidone compound, effectively inhibits the growth of MRSA bacteria and HCoV-229E virus.