Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents

Diabetes mellitus (DM) is a disorder which is raised at the alarming level and it is characterized by the hyperglycemia results from the impaired action of insulin, production of insulin or both of these simultaneously. Consequently, it causes problems or failure of different body organs such as kid...

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Published in:ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Main Authors: Abbasi, Shahzad Ahmad; Rehman, Wajid; Rahim, Fazal; Hussain, Rafaqat; Hawsawi, Mohammed B.; Alluhaibi, Mustafa S.; Alharbi, Majed; Taha, Muhammad; Khan, Shoaib; Rasheed, Liaqat; Wadood, Abdul; Ali Shah, Syed Adnan
Format: Article; Early Access
Language:English
Published: WALTER DE GRUYTER GMBH 2024
Subjects:
Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001359237400001
author Abbasi
Shahzad Ahmad; Rehman
Wajid; Rahim
Fazal; Hussain
Rafaqat; Hawsawi
Mohammed B.; Alluhaibi
Mustafa S.; Alharbi
Majed; Taha
Muhammad; Khan
Shoaib; Rasheed
Liaqat; Wadood
Abdul; Ali Shah
Syed Adnan
spellingShingle Abbasi
Shahzad Ahmad; Rehman
Wajid; Rahim
Fazal; Hussain
Rafaqat; Hawsawi
Mohammed B.; Alluhaibi
Mustafa S.; Alharbi
Majed; Taha
Muhammad; Khan
Shoaib; Rasheed
Liaqat; Wadood
Abdul; Ali Shah
Syed Adnan
Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
Biochemistry & Molecular Biology; Pharmacology & Pharmacy
author_facet Abbasi
Shahzad Ahmad; Rehman
Wajid; Rahim
Fazal; Hussain
Rafaqat; Hawsawi
Mohammed B.; Alluhaibi
Mustafa S.; Alharbi
Majed; Taha
Muhammad; Khan
Shoaib; Rasheed
Liaqat; Wadood
Abdul; Ali Shah
Syed Adnan
author_sort Abbasi
spelling Abbasi, Shahzad Ahmad; Rehman, Wajid; Rahim, Fazal; Hussain, Rafaqat; Hawsawi, Mohammed B.; Alluhaibi, Mustafa S.; Alharbi, Majed; Taha, Muhammad; Khan, Shoaib; Rasheed, Liaqat; Wadood, Abdul; Ali Shah, Syed Adnan
Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
English
Article; Early Access
Diabetes mellitus (DM) is a disorder which is raised at the alarming level and it is characterized by the hyperglycemia results from the impaired action of insulin, production of insulin or both of these simultaneously. Consequently, it causes problems or failure of different body organs such as kidneys, heart, eyes, nerve system. Since this disease cannot be completely cured until now, we aimed to design series of enzymes inhibitors and tested them for DM treatment. In this series, benzimidazole-based thiazolidinone bearing chalcone derivatives completed in a four step reaction and their structures were confirmed through various spectroscopic techniques. A significant efficacy on antidiabetic enzymes was observed, with IC50 values ranging from 25.05 +/- 0.04 to 56.08 +/- 0.07 mu M for alpha-amylase and 22.07 +/- 0.02 to 53.06 +/- 0.07 mu M for alpha-glucosidase. The obtained results were compared to those of the standard glimepiride drug (IC50 = 18.05 +/- 0.07 mu M for alpha-amylase and IC50 = 15.02 +/- 0 .03 mu M for alpha-glucosidase). The synthesized compounds showed promising antidiabetic potency. Moreover, a molecular docking study was conducted on the most active analogs of the compounds to better understand their interactions with the active sites of the targeted enzymes.
WALTER DE GRUYTER GMBH
0939-5075
1865-7125
2024


10.1515/znc-2024-0202
Biochemistry & Molecular Biology; Pharmacology & Pharmacy

WOS:001359237400001
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001359237400001
title Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
title_short Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
title_full Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
title_fullStr Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
title_full_unstemmed Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
title_sort Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
container_title ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
language English
format Article; Early Access
description Diabetes mellitus (DM) is a disorder which is raised at the alarming level and it is characterized by the hyperglycemia results from the impaired action of insulin, production of insulin or both of these simultaneously. Consequently, it causes problems or failure of different body organs such as kidneys, heart, eyes, nerve system. Since this disease cannot be completely cured until now, we aimed to design series of enzymes inhibitors and tested them for DM treatment. In this series, benzimidazole-based thiazolidinone bearing chalcone derivatives completed in a four step reaction and their structures were confirmed through various spectroscopic techniques. A significant efficacy on antidiabetic enzymes was observed, with IC50 values ranging from 25.05 +/- 0.04 to 56.08 +/- 0.07 mu M for alpha-amylase and 22.07 +/- 0.02 to 53.06 +/- 0.07 mu M for alpha-glucosidase. The obtained results were compared to those of the standard glimepiride drug (IC50 = 18.05 +/- 0.07 mu M for alpha-amylase and IC50 = 15.02 +/- 0 .03 mu M for alpha-glucosidase). The synthesized compounds showed promising antidiabetic potency. Moreover, a molecular docking study was conducted on the most active analogs of the compounds to better understand their interactions with the active sites of the targeted enzymes.
publisher WALTER DE GRUYTER GMBH
issn 0939-5075
1865-7125
publishDate 2024
container_volume
container_issue
doi_str_mv 10.1515/znc-2024-0202
topic Biochemistry & Molecular Biology; Pharmacology & Pharmacy
topic_facet Biochemistry & Molecular Biology; Pharmacology & Pharmacy
accesstype
id WOS:001359237400001
url https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001359237400001
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collection Web of Science (WoS)
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