A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
Introduction: The MERIT study in Malaysia is a real-world retrospective, observational, multicenter study that evaluated asthma control in patients with uncontrolled asthma who were switched from as-needed (pro re nata [PRN]) budesonide/formoterol or inhaled corticosteroid (ICS) whenever a short-act...
Published in: | PULMONARY THERAPY |
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Main Authors: | , , , , , , , , , , , , |
Format: | Article; Early Access |
Language: | English |
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2024
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Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001351863500001 |
author |
Ismail Ahmad Izuanuddin; Hyder Ali Irfhan Ali; Wong Chee Kuan; Ban Andrea Yu-Lin; Mz Zahrah Fatimah; Lem Li Khen; Abu Bakar Zamzurina; Alaga Arvindran; Omar Azza; Samsudin Azlina; Lai Siew Li; Gandhi Alap |
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Ismail Ahmad Izuanuddin; Hyder Ali Irfhan Ali; Wong Chee Kuan; Ban Andrea Yu-Lin; Mz Zahrah Fatimah; Lem Li Khen; Abu Bakar Zamzurina; Alaga Arvindran; Omar Azza; Samsudin Azlina; Lai Siew Li; Gandhi Alap A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma Respiratory System |
author_facet |
Ismail Ahmad Izuanuddin; Hyder Ali Irfhan Ali; Wong Chee Kuan; Ban Andrea Yu-Lin; Mz Zahrah Fatimah; Lem Li Khen; Abu Bakar Zamzurina; Alaga Arvindran; Omar Azza; Samsudin Azlina; Lai Siew Li; Gandhi Alap |
author_sort |
Ismail |
spelling |
Ismail, Ahmad Izuanuddin; Hyder Ali, Irfhan Ali; Wong, Chee Kuan; Ban, Andrea Yu-Lin; Mz Zahrah, Fatimah; Lem, Li Khen; Abu Bakar, Zamzurina; Alaga, Arvindran; Omar, Azza; Samsudin, Azlina; Lai, Siew Li; Gandhi, Alap A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma PULMONARY THERAPY English Article; Early Access Introduction: The MERIT study in Malaysia is a real-world retrospective, observational, multicenter study that evaluated asthma control in patients with uncontrolled asthma who were switched from as-needed (pro re nata [PRN]) budesonide/formoterol or inhaled corticosteroid (ICS) whenever a short-acting beta-agonist (SABA) was taken, to proactive regular dosing of fluticasone propionate/salmeterol (FP/SAL PRD). Methods: Data from the medical records of patients who were stepped up to FP/SAL PRD were extracted retrospectively at baseline and follow-up (between 3 and 6 months after stepping up to FP/SAL PRD). The primary endpoint was the percentage of patients with improvement in asthma control assessed via the Asthma Control Test (ACT). Secondary endpoints included safety and the percentage of patients with moderate and severe exacerbations. Additionally, patient-reported use of reliever medication, systemic corticosteroids, emergency department visits, or hospitalization was also analyzed. Results: One hundred twenty patients with uncontrolled asthma who were stepped up to FP/SAL PRD were enrolled in the study. Of these, 76 (63.3%) patients were on prior budesonide/formoterol PRN, and 44 (36.7%) were on prior ICS with SABA PRN treatment. After stepping up to FP/SAL PRD with a mean follow-up of 5.8 months, 110 (91.7%) patients achieved asthma control at the follow-up visit (p < 0.001). Similar improvements were observed regardless of prior PRN regimen. A statistically significant improvement was observed in the mean ACT score at the follow-up visit (p < 0.0001). The proportion of patients with moderate and severe exacerbations was also reduced after stepping up to FP/SAL PRD, with no adverse events reported. Over 80% of patients reported a decrease in the use of systemic corticosteroids, visits to the emergency department, or hospitalization. Conclusion: This study highlights the effectiveness of the FP/SAL PRD treatment approach in patients with uncontrolled asthma on a PRN treatment regimen. SPRINGERNATURE 2364-1754 2364-1746 2024 10.1007/s41030-024-00278-8 Respiratory System gold WOS:001351863500001 https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001351863500001 |
title |
A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma |
title_short |
A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma |
title_full |
A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma |
title_fullStr |
A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma |
title_full_unstemmed |
A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma |
title_sort |
A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma |
container_title |
PULMONARY THERAPY |
language |
English |
format |
Article; Early Access |
description |
Introduction: The MERIT study in Malaysia is a real-world retrospective, observational, multicenter study that evaluated asthma control in patients with uncontrolled asthma who were switched from as-needed (pro re nata [PRN]) budesonide/formoterol or inhaled corticosteroid (ICS) whenever a short-acting beta-agonist (SABA) was taken, to proactive regular dosing of fluticasone propionate/salmeterol (FP/SAL PRD). Methods: Data from the medical records of patients who were stepped up to FP/SAL PRD were extracted retrospectively at baseline and follow-up (between 3 and 6 months after stepping up to FP/SAL PRD). The primary endpoint was the percentage of patients with improvement in asthma control assessed via the Asthma Control Test (ACT). Secondary endpoints included safety and the percentage of patients with moderate and severe exacerbations. Additionally, patient-reported use of reliever medication, systemic corticosteroids, emergency department visits, or hospitalization was also analyzed. Results: One hundred twenty patients with uncontrolled asthma who were stepped up to FP/SAL PRD were enrolled in the study. Of these, 76 (63.3%) patients were on prior budesonide/formoterol PRN, and 44 (36.7%) were on prior ICS with SABA PRN treatment. After stepping up to FP/SAL PRD with a mean follow-up of 5.8 months, 110 (91.7%) patients achieved asthma control at the follow-up visit (p < 0.001). Similar improvements were observed regardless of prior PRN regimen. A statistically significant improvement was observed in the mean ACT score at the follow-up visit (p < 0.0001). The proportion of patients with moderate and severe exacerbations was also reduced after stepping up to FP/SAL PRD, with no adverse events reported. Over 80% of patients reported a decrease in the use of systemic corticosteroids, visits to the emergency department, or hospitalization. Conclusion: This study highlights the effectiveness of the FP/SAL PRD treatment approach in patients with uncontrolled asthma on a PRN treatment regimen. |
publisher |
SPRINGERNATURE |
issn |
2364-1754 2364-1746 |
publishDate |
2024 |
container_volume |
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container_issue |
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doi_str_mv |
10.1007/s41030-024-00278-8 |
topic |
Respiratory System |
topic_facet |
Respiratory System |
accesstype |
gold |
id |
WOS:001351863500001 |
url |
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001351863500001 |
record_format |
wos |
collection |
Web of Science (WoS) |
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1818940501258141696 |