Anti-inflammatory Activity of 1-Substituted Glyoxal β- Carboline Derivatives

• Published in: MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES
• Main Authors: Zulkifli, Siti Zafirah; Asha'ari, Nur Ain Nabilah; Aziz, Ahmad Fawwaz Aiman; Pungot, Noor Hidayah
• Format: Article
• Language: English
• Published: PENERBIT UTM PRESS 2024
• Subjects: Science & Technology - Other Topics
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001338878300018
• ISSN: 2289-5981; 2289-599X
• DOI: 10.11113/mjfas.v20n5.3630

The anti-inflammatory properties of R-carbolines have been widely studied, highlighting their potential in treating inflammatory disorders. This research investigates the antiinflammatory activity of selected 1-substituted glyoxal R-carboline derivatives, achieved through a one-step conversion of 5-hydroxy-L-tryptophan with activated glyoxal, without forming tetrahydroR-carboline (THRC) intermediates. These derivatives (4e 4e-g ) were synthesized successfully without requiring expensive metal catalysts, prolonged reaction times, or stringent reaction conditions, and yielded moderate amounts. Our findings indicate that all the derivatives significantly inhibit xanthine oxidase (XO) activity, leading to a reduction in reactive oxygen species (ROS) and free radicals. This inhibition disrupts the inflammatory cascade and attenuates the inflammatory response.