The risk of prenatal bisphenol A exposure in early life neurodevelopment: Insights from epigenetic regulation

• Published in: EARLY HUMAN DEVELOPMENT
• Main Authors: Nayan, Norazirah Mat; Husin, Andrean; Siran, Rosfaiizah
• Format: Article
• Language: English
• Published: ELSEVIER IRELAND LTD 2024
• Subjects: Obstetrics & Gynecology; Pediatrics
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001318113200001
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2024.106120

Bisphenols are mainly used as protective coatings for plastics and resin-based materials in various consumer products. Industrial producers have a high demand for bisphenol A (BPA) among all bisphenol substitutes for various consumer products. However, according to reports, prolonged exposure to BPA can cause multiple health issues, including neurodevelopmental disorders in young children. BPA exposure during pregnancy has been considered as the primary cause of increasing the risk of neurological disorders in children as their neural systems are designed to respond to any environmental changes during prenatal life. Recently, there has been an increased focus on the effects of prenatal exposure to BPA, as it has been found to alter gene expression related to epigenetic mechanisms like DNA methylation, histone modification, and microRNA expression. Based on the evidence, frequent interactions can lead to inherited changes in an individual's neural profile. In this review, we delve into the current knowledge regarding the toxicity mechanism of BPA for expecting mothers. Next, we will discuss the possible action of BPA on the epigenetic mechanism during brain development. This is especially important to portray an overview on the role of epigenetic modification caused by prenatal BPA exposure and next, give future directions for improving human health risk assessment caused by BPA exposure.