Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery

Exosomes are small vesicles that form when multivesicular bodies fuse with the plasma membrane and are released into body fluids. They play a vital role in facilitating communication between cells by transferring different biomolecules, including DNA, RNA, proteins, and lipids, over both short and l...

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Published in:MOLECULAR BIOTECHNOLOGY
Main Authors: Al-Ani, Safa Ali; Lee, Qiao Ying; Maheswaran, Danesha; Sin, Yuh Miin; Loh, Jian Sheng; Foo, Jhi Biau; Hamzah, Sharina; Ng, Jeck Fei; Tan, Li Kar Stella
Format: Review; Early Access
Language:English
Published: SPRINGERNATURE 2024
Subjects:
Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001311962000002
author Al-Ani
Safa Ali; Lee
Qiao Ying; Maheswaran
Danesha; Sin
Yuh Miin; Loh
Jian Sheng; Foo
Jhi Biau; Hamzah
Sharina; Ng
Jeck Fei; Tan
Li Kar Stella
spellingShingle Al-Ani
Safa Ali; Lee
Qiao Ying; Maheswaran
Danesha; Sin
Yuh Miin; Loh
Jian Sheng; Foo
Jhi Biau; Hamzah
Sharina; Ng
Jeck Fei; Tan
Li Kar Stella
Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
author_facet Al-Ani
Safa Ali; Lee
Qiao Ying; Maheswaran
Danesha; Sin
Yuh Miin; Loh
Jian Sheng; Foo
Jhi Biau; Hamzah
Sharina; Ng
Jeck Fei; Tan
Li Kar Stella
author_sort Al-Ani
spelling Al-Ani, Safa Ali; Lee, Qiao Ying; Maheswaran, Danesha; Sin, Yuh Miin; Loh, Jian Sheng; Foo, Jhi Biau; Hamzah, Sharina; Ng, Jeck Fei; Tan, Li Kar Stella
Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
MOLECULAR BIOTECHNOLOGY
English
Review; Early Access
Exosomes are small vesicles that form when multivesicular bodies fuse with the plasma membrane and are released into body fluids. They play a vital role in facilitating communication between cells by transferring different biomolecules, including DNA, RNA, proteins, and lipids, over both short and long distances. They also function as vital mediators in both states of health and disease, exerting an impact on several physiological processes. Exosomes have been modified to overcome the limitations of natural exosomes to enhance their potential as carriers for drug delivery systems, and these modifications aim to improve the drug delivery efficiency, enhance tissue and organ targeting, and prolong the circulating half-life of exosomes. This review discussed recent advancements in exosome nanotechnology, as well as the progression and use of exosomes for drug delivery. The potential commercialisation and challenges associated with the use of exosome-based drug delivery systems were also discussed, aiming to motivate the development of exosome-based theranostic nanoplatforms and nanotechnology for improved healthcare treatments.
SPRINGERNATURE
1073-6085
1559-0305
2024


10.1007/s12033-024-01268-6
Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology

WOS:001311962000002
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001311962000002
title Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
title_short Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
title_full Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
title_fullStr Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
title_full_unstemmed Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
title_sort Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
container_title MOLECULAR BIOTECHNOLOGY
language English
format Review; Early Access
description Exosomes are small vesicles that form when multivesicular bodies fuse with the plasma membrane and are released into body fluids. They play a vital role in facilitating communication between cells by transferring different biomolecules, including DNA, RNA, proteins, and lipids, over both short and long distances. They also function as vital mediators in both states of health and disease, exerting an impact on several physiological processes. Exosomes have been modified to overcome the limitations of natural exosomes to enhance their potential as carriers for drug delivery systems, and these modifications aim to improve the drug delivery efficiency, enhance tissue and organ targeting, and prolong the circulating half-life of exosomes. This review discussed recent advancements in exosome nanotechnology, as well as the progression and use of exosomes for drug delivery. The potential commercialisation and challenges associated with the use of exosome-based drug delivery systems were also discussed, aiming to motivate the development of exosome-based theranostic nanoplatforms and nanotechnology for improved healthcare treatments.
publisher SPRINGERNATURE
issn 1073-6085
1559-0305
publishDate 2024
container_volume
container_issue
doi_str_mv 10.1007/s12033-024-01268-6
topic Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
topic_facet Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
accesstype
id WOS:001311962000002
url https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001311962000002
record_format wos
collection Web of Science (WoS)
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