Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes

Preeclampsia (PE), caused by multiple factors, is one of the most serious complications of pregnancy. Cadmium (Cd) is a heavy metal environmental pollutant, reproductive toxicant, and endocrine disruptor, which can increase the risk of PE. Cd toxicity due to occupational, diet, and environmental fac...

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Published in:BIOLOGICAL TRACE ELEMENT RESEARCH
Main Authors: Sardar, Fatima; Kamsani, Yuhaniza Shafinie; Ramly, Fathi; Khan, Nor Ashikin Mohamed Noor; Sardar, Razia; Aminuddin, Anisa Aishah
Format: Review; Early Access
Language:English
Published: SPRINGERNATURE 2024
Subjects:
Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001309928500004
author Sardar
Fatima; Kamsani
Yuhaniza Shafinie; Ramly
Fathi; Khan
Nor Ashikin Mohamed Noor; Sardar
Razia; Aminuddin
Anisa Aishah
spellingShingle Sardar
Fatima; Kamsani
Yuhaniza Shafinie; Ramly
Fathi; Khan
Nor Ashikin Mohamed Noor; Sardar
Razia; Aminuddin
Anisa Aishah
Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes
Biochemistry & Molecular Biology; Endocrinology & Metabolism
author_facet Sardar
Fatima; Kamsani
Yuhaniza Shafinie; Ramly
Fathi; Khan
Nor Ashikin Mohamed Noor; Sardar
Razia; Aminuddin
Anisa Aishah
author_sort Sardar
spelling Sardar, Fatima; Kamsani, Yuhaniza Shafinie; Ramly, Fathi; Khan, Nor Ashikin Mohamed Noor; Sardar, Razia; Aminuddin, Anisa Aishah
Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes
BIOLOGICAL TRACE ELEMENT RESEARCH
English
Review; Early Access
Preeclampsia (PE), caused by multiple factors, is one of the most serious complications of pregnancy. Cadmium (Cd) is a heavy metal environmental pollutant, reproductive toxicant, and endocrine disruptor, which can increase the risk of PE. Cd toxicity due to occupational, diet, and environmental factors has worsened the risk. Studies showed elevated Cd concentration in maternal blood and placenta of PE women. However, the implicit association between Cd associated PE is still not highlighted. We systematically reviewed Cd-associated PE and its effect on pregnancy and birth outcomes. Based on Preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, eighty-six studies were identified by PubMed, Web of Science (WOS), and Scopus databases. Publications were included until October 2023 and articles screened based on our inclusion criteria. Our study identified that the exposure of controlled and uncontrolled Cd induces PE, which negatively affects pregnancy and birth outcomes. Given the serious nature of this finding, Cd is a potential adverse agent that impacts pregnancy and future neonatal health. Further comprehensive studies covering the whole trimesters of pregnancy and neonatal developments are warranted. Data on the molecular mechanisms behind Cd-induced PE is also essential for potential preventive, diagnostic, or therapeutic targets.
SPRINGERNATURE
0163-4984
1559-0720
2024


10.1007/s12011-024-04364-5
Biochemistry & Molecular Biology; Endocrinology & Metabolism

WOS:001309928500004
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001309928500004
title Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes
title_short Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes
title_full Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes
title_fullStr Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes
title_full_unstemmed Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes
title_sort Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes
container_title BIOLOGICAL TRACE ELEMENT RESEARCH
language English
format Review; Early Access
description Preeclampsia (PE), caused by multiple factors, is one of the most serious complications of pregnancy. Cadmium (Cd) is a heavy metal environmental pollutant, reproductive toxicant, and endocrine disruptor, which can increase the risk of PE. Cd toxicity due to occupational, diet, and environmental factors has worsened the risk. Studies showed elevated Cd concentration in maternal blood and placenta of PE women. However, the implicit association between Cd associated PE is still not highlighted. We systematically reviewed Cd-associated PE and its effect on pregnancy and birth outcomes. Based on Preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, eighty-six studies were identified by PubMed, Web of Science (WOS), and Scopus databases. Publications were included until October 2023 and articles screened based on our inclusion criteria. Our study identified that the exposure of controlled and uncontrolled Cd induces PE, which negatively affects pregnancy and birth outcomes. Given the serious nature of this finding, Cd is a potential adverse agent that impacts pregnancy and future neonatal health. Further comprehensive studies covering the whole trimesters of pregnancy and neonatal developments are warranted. Data on the molecular mechanisms behind Cd-induced PE is also essential for potential preventive, diagnostic, or therapeutic targets.
publisher SPRINGERNATURE
issn 0163-4984
1559-0720
publishDate 2024
container_volume
container_issue
doi_str_mv 10.1007/s12011-024-04364-5
topic Biochemistry & Molecular Biology; Endocrinology & Metabolism
topic_facet Biochemistry & Molecular Biology; Endocrinology & Metabolism
accesstype
id WOS:001309928500004
url https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001309928500004
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