Exploring Acyl Thiotriazinoindole Based Pharmacophores: Design, Synthesis, and SAR Studies with Molecular Docking and Biological Activity Profiling against Urease, α-amylase, α-glucosidase, Antimicrobial, and Antioxidant Targets

A diminutive chemical library of acyl thiotriazinoindole (ATTI) based bioactive scaffolds was synthesized, instigated by taking the economical starting material Isatin, through a series of five steps. Isatin was first nitrated followed by the attachment of pentyl moiety via nucleophilic substitution...

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Bibliographic Details
Published in:PROTEIN JOURNAL
Main Authors: Haider, Mian Bilal; Saeed, Aamer; Ahmed, Atteeque; Azeem, Muhammad; Ismail, Hammad; Mehmood, Sabba; Taslimi, Parham; Shah, Syed Adnan Ali; Irfan, Madiha; El-Seedi, Hesham R.
Format: Article
Language:English
Published: SPRINGER 2024
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Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001303880000001

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