Review and expert opinion on MAFLD, oxidative stress and multifunctional management

Metabolic-associated fatty-liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is the most widespread and emerging chronic liver disease worldwide, with increasing prevalence rates also in the Asia-Pacific region. The disease has a high socio-economic burden as it negativel...

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Published in:DRUGS IN CONTEXT
Main Authors: Angelico, Francesco; Alcantara-Payawal, Diana; Rani, Rafiz Abdul; Mustafa, Norlaila; Thongtang, Nuntakorn; Chaiteerakij, Roongruedee; Bunchorntavakul, Chalermrat; Sukonthasarn, Apichard
Format: Review
Language:English
Published: BIOEXCEL PUBL LTD 2024
Subjects:
Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001280127100001
author Angelico
Francesco; Alcantara-Payawal
Diana; Rani
Rafiz Abdul; Mustafa
Norlaila; Thongtang
Nuntakorn; Chaiteerakij
Roongruedee; Bunchorntavakul
Chalermrat; Sukonthasarn
Apichard
spellingShingle Angelico
Francesco; Alcantara-Payawal
Diana; Rani
Rafiz Abdul; Mustafa
Norlaila; Thongtang
Nuntakorn; Chaiteerakij
Roongruedee; Bunchorntavakul
Chalermrat; Sukonthasarn
Apichard
Review and expert opinion on MAFLD, oxidative stress and multifunctional management
Pharmacology & Pharmacy
author_facet Angelico
Francesco; Alcantara-Payawal
Diana; Rani
Rafiz Abdul; Mustafa
Norlaila; Thongtang
Nuntakorn; Chaiteerakij
Roongruedee; Bunchorntavakul
Chalermrat; Sukonthasarn
Apichard
author_sort Angelico
spelling Angelico, Francesco; Alcantara-Payawal, Diana; Rani, Rafiz Abdul; Mustafa, Norlaila; Thongtang, Nuntakorn; Chaiteerakij, Roongruedee; Bunchorntavakul, Chalermrat; Sukonthasarn, Apichard
Review and expert opinion on MAFLD, oxidative stress and multifunctional management
DRUGS IN CONTEXT
English
Review
Metabolic-associated fatty-liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is the most widespread and emerging chronic liver disease worldwide, with increasing prevalence rates also in the Asia-Pacific region. The disease has a high socio-economic burden as it negatively impacts the finances and quality of life of individuals affected and has a major burden on healthcare systems. The most important pathological event in MAFLD aetiopathogenesis is oxidative stress, which leads to functional and structural abnormalities in the liver as well as being involved in the development of other concomitant cardiometabolic diseases. MAFLD is a rather complex multisystemic clinical condition involving liver damage and a wide spectrum of extrahepatic manifestations such as obesity, type 2 diabetes, metabolic syndrome and cardiovascular diseases. This complexity requires the cooperation of multiple experts to identify MAFLD at an early stage, treat associated comorbidities, and promptly refer the patient to the hepatologist when needed. This review summarizes the current knowledge about MAFLD and reports the opinion of a group of experts on the increasing prevalence and burden of the disease in the southeast Asia region, the current journey of patients with MAFLD in developing countries, the role of oxidative stress and antioxidant treatment, and the importance of a multidisciplinary approach for early diagnosis and disease management.
BIOEXCEL PUBL LTD

1740-4398
2024
13

10.7573/dic.2023-9-3
Pharmacology & Pharmacy
Green Published, gold
WOS:001280127100001
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001280127100001
title Review and expert opinion on MAFLD, oxidative stress and multifunctional management
title_short Review and expert opinion on MAFLD, oxidative stress and multifunctional management
title_full Review and expert opinion on MAFLD, oxidative stress and multifunctional management
title_fullStr Review and expert opinion on MAFLD, oxidative stress and multifunctional management
title_full_unstemmed Review and expert opinion on MAFLD, oxidative stress and multifunctional management
title_sort Review and expert opinion on MAFLD, oxidative stress and multifunctional management
container_title DRUGS IN CONTEXT
language English
format Review
description Metabolic-associated fatty-liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is the most widespread and emerging chronic liver disease worldwide, with increasing prevalence rates also in the Asia-Pacific region. The disease has a high socio-economic burden as it negatively impacts the finances and quality of life of individuals affected and has a major burden on healthcare systems. The most important pathological event in MAFLD aetiopathogenesis is oxidative stress, which leads to functional and structural abnormalities in the liver as well as being involved in the development of other concomitant cardiometabolic diseases. MAFLD is a rather complex multisystemic clinical condition involving liver damage and a wide spectrum of extrahepatic manifestations such as obesity, type 2 diabetes, metabolic syndrome and cardiovascular diseases. This complexity requires the cooperation of multiple experts to identify MAFLD at an early stage, treat associated comorbidities, and promptly refer the patient to the hepatologist when needed. This review summarizes the current knowledge about MAFLD and reports the opinion of a group of experts on the increasing prevalence and burden of the disease in the southeast Asia region, the current journey of patients with MAFLD in developing countries, the role of oxidative stress and antioxidant treatment, and the importance of a multidisciplinary approach for early diagnosis and disease management.
publisher BIOEXCEL PUBL LTD
issn
1740-4398
publishDate 2024
container_volume 13
container_issue
doi_str_mv 10.7573/dic.2023-9-3
topic Pharmacology & Pharmacy
topic_facet Pharmacology & Pharmacy
accesstype Green Published, gold
id WOS:001280127100001
url https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001280127100001
record_format wos
collection Web of Science (WoS)
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