Applications of CRISPR in Parasitology
Clustered Regions of Interspersed Palindromic Repeat (CRISPR)-based techniques have been utilized in various research areas, including agriculture, biotechnology, and medicine. With the use of a short sequence guide RNA and CRISPR-associated (Cas) protein, this technique allows for robust, site-spec...
Published in: | CURRENT PHARMACEUTICAL BIOTECHNOLOGY |
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Main Authors: | , , , , , , , , , |
Format: | Review; Early Access |
Language: | English |
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BENTHAM SCIENCE PUBL LTD
2024
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Subjects: | |
Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001276130600001 |
author |
Tee Phoebe Yon Ern; Chu Sylvester Yee Chun; Kok Chloe Chien Yee; Foo Mun; Tan Clarence Zhen Jin; Foo Jhi Biau; Hatta Fazleen Haslinda Mohd; Tan Li Kar Stella; Hamzah Sharina |
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Tee Phoebe Yon Ern; Chu Sylvester Yee Chun; Kok Chloe Chien Yee; Foo Mun; Tan Clarence Zhen Jin; Foo Jhi Biau; Hatta Fazleen Haslinda Mohd; Tan Li Kar Stella; Hamzah Sharina Applications of CRISPR in Parasitology Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
author_facet |
Tee Phoebe Yon Ern; Chu Sylvester Yee Chun; Kok Chloe Chien Yee; Foo Mun; Tan Clarence Zhen Jin; Foo Jhi Biau; Hatta Fazleen Haslinda Mohd; Tan Li Kar Stella; Hamzah Sharina |
author_sort |
Tee |
spelling |
Tee, Phoebe Yon Ern; Chu, Sylvester Yee Chun; Kok, Chloe Chien Yee; Foo, Mun; Tan, Clarence Zhen Jin; Foo, Jhi Biau; Hatta, Fazleen Haslinda Mohd; Tan, Li Kar Stella; Hamzah, Sharina Applications of CRISPR in Parasitology CURRENT PHARMACEUTICAL BIOTECHNOLOGY English Review; Early Access Clustered Regions of Interspersed Palindromic Repeat (CRISPR)-based techniques have been utilized in various research areas, including agriculture, biotechnology, and medicine. With the use of a short sequence guide RNA and CRISPR-associated (Cas) protein, this technique allows for robust, site-specific manipulation of the genome, aiding researchers in making important biomedical discoveries and scientific advancements. In this review, we explored the applications of CRISPR/Cas systems in the field of parasitology for the identification and validation of novel functional genes, diagnosis of parasitic infections, reduction of parasite virulence, and the disruption of disease transmission. We also discussed how CRISPR can be used for the development of therapeutics, vaccines, and drug discovery. Furthermore, the challenges and future perspectives of this technology are also highlighted. BENTHAM SCIENCE PUBL LTD 1389-2010 1873-4316 2024 10.2174/0113892010316710240626042205 Biochemistry & Molecular Biology; Pharmacology & Pharmacy WOS:001276130600001 https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001276130600001 |
title |
Applications of CRISPR in Parasitology |
title_short |
Applications of CRISPR in Parasitology |
title_full |
Applications of CRISPR in Parasitology |
title_fullStr |
Applications of CRISPR in Parasitology |
title_full_unstemmed |
Applications of CRISPR in Parasitology |
title_sort |
Applications of CRISPR in Parasitology |
container_title |
CURRENT PHARMACEUTICAL BIOTECHNOLOGY |
language |
English |
format |
Review; Early Access |
description |
Clustered Regions of Interspersed Palindromic Repeat (CRISPR)-based techniques have been utilized in various research areas, including agriculture, biotechnology, and medicine. With the use of a short sequence guide RNA and CRISPR-associated (Cas) protein, this technique allows for robust, site-specific manipulation of the genome, aiding researchers in making important biomedical discoveries and scientific advancements. In this review, we explored the applications of CRISPR/Cas systems in the field of parasitology for the identification and validation of novel functional genes, diagnosis of parasitic infections, reduction of parasite virulence, and the disruption of disease transmission. We also discussed how CRISPR can be used for the development of therapeutics, vaccines, and drug discovery. Furthermore, the challenges and future perspectives of this technology are also highlighted. |
publisher |
BENTHAM SCIENCE PUBL LTD |
issn |
1389-2010 1873-4316 |
publishDate |
2024 |
container_volume |
|
container_issue |
|
doi_str_mv |
10.2174/0113892010316710240626042205 |
topic |
Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
topic_facet |
Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
accesstype |
|
id |
WOS:001276130600001 |
url |
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001276130600001 |
record_format |
wos |
collection |
Web of Science (WoS) |
_version_ |
1809679297501200384 |