Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities
Amorphous solid dispersion (ASD) has emerged to be an outstanding strategy among multiple options available for improving solubility and consequently biological activity. Interestingly several binary SD systems continue to exhibit insufficient solubility over time. Therefore, the goal of current res...
Published in: | HELIYON |
---|---|
Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Published: |
CELL PRESS
2024
|
Subjects: | |
Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001274329000001 |
author |
Ishtiaq Memoona; Manzoor Hina; Khan Ikram Ullah; Asghar Sajid; Irfan Muhammad; Albekairi Norah A.; Alshammari Abdulrahman; Alqahtani Abdulrahman F.; Alotaibi Saad; Munir Rabia; Shah Pervaiz A.; Hussain Liaqat; Saleem Muhammad Abubakar; Razzaq Fizza Abdul; Khalid Syed Haroon |
---|---|
spellingShingle |
Ishtiaq Memoona; Manzoor Hina; Khan Ikram Ullah; Asghar Sajid; Irfan Muhammad; Albekairi Norah A.; Alshammari Abdulrahman; Alqahtani Abdulrahman F.; Alotaibi Saad; Munir Rabia; Shah Pervaiz A.; Hussain Liaqat; Saleem Muhammad Abubakar; Razzaq Fizza Abdul; Khalid Syed Haroon Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities Science & Technology - Other Topics |
author_facet |
Ishtiaq Memoona; Manzoor Hina; Khan Ikram Ullah; Asghar Sajid; Irfan Muhammad; Albekairi Norah A.; Alshammari Abdulrahman; Alqahtani Abdulrahman F.; Alotaibi Saad; Munir Rabia; Shah Pervaiz A.; Hussain Liaqat; Saleem Muhammad Abubakar; Razzaq Fizza Abdul; Khalid Syed Haroon |
author_sort |
Ishtiaq |
spelling |
Ishtiaq, Memoona; Manzoor, Hina; Khan, Ikram Ullah; Asghar, Sajid; Irfan, Muhammad; Albekairi, Norah A.; Alshammari, Abdulrahman; Alqahtani, Abdulrahman F.; Alotaibi, Saad; Munir, Rabia; Shah, Pervaiz A.; Hussain, Liaqat; Saleem, Muhammad Abubakar; Razzaq, Fizza Abdul; Khalid, Syed Haroon Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities HELIYON English Article Amorphous solid dispersion (ASD) has emerged to be an outstanding strategy among multiple options available for improving solubility and consequently biological activity. Interestingly several binary SD systems continue to exhibit insufficient solubility over time. Therefore, the goal of current research was to design ternary amorphous solid dispersions (ASDs) of hydrophobic model drug curcumin (CUR) to enhance the solubility and dissolution rate in turn, presenting enhanced anti-bacterial, antioxidant and anti-inflammatory activity. For this purpose several ternary solid dispersions (TSDs) consisting of Soluplus (R), Syloid (R) XDP 3150, Syloid (R) 244 and Poloxamer (R) 188 in combination with HPMC E5 (binary carrier) were prepared using solvent evaporation method. Both solubility and dissolution testing of prepared solid dispersion were performed to determine the increase in solubility and dissolution. Solid state investigation was carried out utilizing infrared spectroscopy, also known as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM),Differential scanning calorimetry (DSC) and X-ray diffraction (XRD).Optimized formulations were also tested for their biological effectiveness including anti-bacterial, anti-oxidant and anti-inflammatory activity. Amid all Ternary formulations F3 entailing 20 % soluplus (R) remarkably improved the solubility (186 mu g/ml +/- 3.95) and consequently dissolution (91 % +/- 3.89 %) of curcumin by 3100 and 9 fold respectively. These finding were also supported by FTIR, SEM, XRD and DSC. In-vitro antibacterial investigation of F3 also demonstrated significant improvement in antibacterial activity against both gram positive (Staphylococcus aureus, Bacillus cereus) and gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria. Among all the tested strains Staphylococcus aureus was found to be most susceptible with a zone of inhibition of 24 mm f 2.87. Antioxidant activity of F3 was also notably enhanced (93 % f 5.30) in contrast to CUR (69 % f 4.79). In vitro anti-inflammatory assessment also exhibited that F3 markedly protected BSA (bovine serum albumin) from denaturation with percent BSA inhibition of 80 % f 3.16 in comparison to CUR (49 % f 2.91). Hence, F3 could be an effective solid dispersion system for the delivery of model hydrophobic drug curcumin. CELL PRESS 2405-8440 2024 10 14 10.1016/j.heliyon.2024.e34636 Science & Technology - Other Topics WOS:001274329000001 https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001274329000001 |
title |
Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities |
title_short |
Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities |
title_full |
Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities |
title_fullStr |
Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities |
title_full_unstemmed |
Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities |
title_sort |
Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities |
container_title |
HELIYON |
language |
English |
format |
Article |
description |
Amorphous solid dispersion (ASD) has emerged to be an outstanding strategy among multiple options available for improving solubility and consequently biological activity. Interestingly several binary SD systems continue to exhibit insufficient solubility over time. Therefore, the goal of current research was to design ternary amorphous solid dispersions (ASDs) of hydrophobic model drug curcumin (CUR) to enhance the solubility and dissolution rate in turn, presenting enhanced anti-bacterial, antioxidant and anti-inflammatory activity. For this purpose several ternary solid dispersions (TSDs) consisting of Soluplus (R), Syloid (R) XDP 3150, Syloid (R) 244 and Poloxamer (R) 188 in combination with HPMC E5 (binary carrier) were prepared using solvent evaporation method. Both solubility and dissolution testing of prepared solid dispersion were performed to determine the increase in solubility and dissolution. Solid state investigation was carried out utilizing infrared spectroscopy, also known as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM),Differential scanning calorimetry (DSC) and X-ray diffraction (XRD).Optimized formulations were also tested for their biological effectiveness including anti-bacterial, anti-oxidant and anti-inflammatory activity. Amid all Ternary formulations F3 entailing 20 % soluplus (R) remarkably improved the solubility (186 mu g/ml +/- 3.95) and consequently dissolution (91 % +/- 3.89 %) of curcumin by 3100 and 9 fold respectively. These finding were also supported by FTIR, SEM, XRD and DSC. In-vitro antibacterial investigation of F3 also demonstrated significant improvement in antibacterial activity against both gram positive (Staphylococcus aureus, Bacillus cereus) and gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria. Among all the tested strains Staphylococcus aureus was found to be most susceptible with a zone of inhibition of 24 mm f 2.87. Antioxidant activity of F3 was also notably enhanced (93 % f 5.30) in contrast to CUR (69 % f 4.79). In vitro anti-inflammatory assessment also exhibited that F3 markedly protected BSA (bovine serum albumin) from denaturation with percent BSA inhibition of 80 % f 3.16 in comparison to CUR (49 % f 2.91). Hence, F3 could be an effective solid dispersion system for the delivery of model hydrophobic drug curcumin. |
publisher |
CELL PRESS |
issn |
2405-8440 |
publishDate |
2024 |
container_volume |
10 |
container_issue |
14 |
doi_str_mv |
10.1016/j.heliyon.2024.e34636 |
topic |
Science & Technology - Other Topics |
topic_facet |
Science & Technology - Other Topics |
accesstype |
|
id |
WOS:001274329000001 |
url |
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001274329000001 |
record_format |
wos |
collection |
Web of Science (WoS) |
_version_ |
1809679210588930048 |