Golgi apparatus targeted therapy in cancer: Are we there yet?

Membrane trafficking within the Golgi apparatus plays a pivotal role in the intracellular transportation of lipids and proteins. Dysregulation of this process can give rise to various pathological manifestations, including cancer. Exploiting Golgi defects, cancer cells capitalise on aberrant membran...

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Published in:LIFE SCIENCES
Main Authors: Lee, Zheng Yang; Lee, Wen Hwei; Lim, Jing Sheng; Ali, Afiqah Ali Ajmel; Loo, Jason Siau Ee; Wibowo, Agustono; Mohammat, Mohd Fazli; Foo, Jhi Biau
Format: Article
Language:English
Published: PERGAMON-ELSEVIER SCIENCE LTD 2024
Subjects:
Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001263515200001
author Lee
Zheng Yang; Lee
Wen Hwei; Lim
Jing Sheng; Ali
Afiqah Ali Ajmel; Loo
Jason Siau Ee; Wibowo
Agustono; Mohammat
Mohd Fazli; Foo
Jhi Biau
spellingShingle Lee
Zheng Yang; Lee
Wen Hwei; Lim
Jing Sheng; Ali
Afiqah Ali Ajmel; Loo
Jason Siau Ee; Wibowo
Agustono; Mohammat
Mohd Fazli; Foo
Jhi Biau
Golgi apparatus targeted therapy in cancer: Are we there yet?
Research & Experimental Medicine; Pharmacology & Pharmacy
author_facet Lee
Zheng Yang; Lee
Wen Hwei; Lim
Jing Sheng; Ali
Afiqah Ali Ajmel; Loo
Jason Siau Ee; Wibowo
Agustono; Mohammat
Mohd Fazli; Foo
Jhi Biau
author_sort Lee
spelling Lee, Zheng Yang; Lee, Wen Hwei; Lim, Jing Sheng; Ali, Afiqah Ali Ajmel; Loo, Jason Siau Ee; Wibowo, Agustono; Mohammat, Mohd Fazli; Foo, Jhi Biau
Golgi apparatus targeted therapy in cancer: Are we there yet?
LIFE SCIENCES
English
Article
Membrane trafficking within the Golgi apparatus plays a pivotal role in the intracellular transportation of lipids and proteins. Dysregulation of this process can give rise to various pathological manifestations, including cancer. Exploiting Golgi defects, cancer cells capitalise on aberrant membrane trafficking to facilitate signal transduction, proliferation, invasion, immune modulation, angiogenesis, and metastasis. Despite the identification of several molecular signalling pathways associated with Golgi abnormalities, there remains a lack of approved drugs specifically targeting cancer cells through the manipulation of the Golgi apparatus. In the initial section of this comprehensive review, the focus is directed towards delineating the abnormal Golgi genes and proteins implicated in carcinogenesis. Subsequently, a thorough examination is conducted on the impact of these variations on Golgi function, encompassing aspects such as vesicular trafficking, glycosylation, autophagy, oxidative mechanisms, and pH alterations. Lastly, the review provides a current update on promising Golgi apparatustargeted inhibitors undergoing preclinical and/or clinical trials, offering insights into their potential as therapeutic interventions. Significantly more effort is required to advance these potential inhibitors to benefit patients in clinical settings.
PERGAMON-ELSEVIER SCIENCE LTD
0024-3205
1879-0631
2024
352

10.1016/j.lfs.2024.122868
Research & Experimental Medicine; Pharmacology & Pharmacy

WOS:001263515200001
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001263515200001
title Golgi apparatus targeted therapy in cancer: Are we there yet?
title_short Golgi apparatus targeted therapy in cancer: Are we there yet?
title_full Golgi apparatus targeted therapy in cancer: Are we there yet?
title_fullStr Golgi apparatus targeted therapy in cancer: Are we there yet?
title_full_unstemmed Golgi apparatus targeted therapy in cancer: Are we there yet?
title_sort Golgi apparatus targeted therapy in cancer: Are we there yet?
container_title LIFE SCIENCES
language English
format Article
description Membrane trafficking within the Golgi apparatus plays a pivotal role in the intracellular transportation of lipids and proteins. Dysregulation of this process can give rise to various pathological manifestations, including cancer. Exploiting Golgi defects, cancer cells capitalise on aberrant membrane trafficking to facilitate signal transduction, proliferation, invasion, immune modulation, angiogenesis, and metastasis. Despite the identification of several molecular signalling pathways associated with Golgi abnormalities, there remains a lack of approved drugs specifically targeting cancer cells through the manipulation of the Golgi apparatus. In the initial section of this comprehensive review, the focus is directed towards delineating the abnormal Golgi genes and proteins implicated in carcinogenesis. Subsequently, a thorough examination is conducted on the impact of these variations on Golgi function, encompassing aspects such as vesicular trafficking, glycosylation, autophagy, oxidative mechanisms, and pH alterations. Lastly, the review provides a current update on promising Golgi apparatustargeted inhibitors undergoing preclinical and/or clinical trials, offering insights into their potential as therapeutic interventions. Significantly more effort is required to advance these potential inhibitors to benefit patients in clinical settings.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0024-3205
1879-0631
publishDate 2024
container_volume 352
container_issue
doi_str_mv 10.1016/j.lfs.2024.122868
topic Research & Experimental Medicine; Pharmacology & Pharmacy
topic_facet Research & Experimental Medicine; Pharmacology & Pharmacy
accesstype
id WOS:001263515200001
url https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001263515200001
record_format wos
collection Web of Science (WoS)
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