Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells

Nanomedicine is the application of nanomaterials and nanotechnology to the development of novel pharmaceuticals and drug delivery mechanisms. The present study synthesized a functionalized nanocomposite (NC) containing graphene oxide (GO), chitosan (Ch), manganese (Mn), folic acid (FA), and brucine....

Full description

Bibliographic Details
Published in:GREEN PROCESSING AND SYNTHESIS
Main Authors: Alzahrani, Abdullah R.; Ibrahim, Ibrahim Abdel Aziz; Alanazi, Ibrahim M.; Shahzad, Naiyer; Shahid, Imran; Nur Azlina, Mohd Fahami; Kamisah, Yusof; Ismail, Nafeeza Mohd; Arulselvan, Palanisamy
Format: Article
Language:English
Published: DE GRUYTER POLAND SP Z O O 2024
Subjects:
Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001262637800001
author Alzahrani
Abdullah R.; Ibrahim
Ibrahim Abdel Aziz; Alanazi
Ibrahim M.; Shahzad
Naiyer; Shahid
Imran; Nur Azlina
Mohd Fahami; Kamisah
Yusof; Ismail
Nafeeza Mohd; Arulselvan
Palanisamy
spellingShingle Alzahrani
Abdullah R.; Ibrahim
Ibrahim Abdel Aziz; Alanazi
Ibrahim M.; Shahzad
Naiyer; Shahid
Imran; Nur Azlina
Mohd Fahami; Kamisah
Yusof; Ismail
Nafeeza Mohd; Arulselvan
Palanisamy
Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
Chemistry; Science & Technology - Other Topics; Engineering
author_facet Alzahrani
Abdullah R.; Ibrahim
Ibrahim Abdel Aziz; Alanazi
Ibrahim M.; Shahzad
Naiyer; Shahid
Imran; Nur Azlina
Mohd Fahami; Kamisah
Yusof; Ismail
Nafeeza Mohd; Arulselvan
Palanisamy
author_sort Alzahrani
spelling Alzahrani, Abdullah R.; Ibrahim, Ibrahim Abdel Aziz; Alanazi, Ibrahim M.; Shahzad, Naiyer; Shahid, Imran; Nur Azlina, Mohd Fahami; Kamisah, Yusof; Ismail, Nafeeza Mohd; Arulselvan, Palanisamy
Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
GREEN PROCESSING AND SYNTHESIS
English
Article
Nanomedicine is the application of nanomaterials and nanotechnology to the development of novel pharmaceuticals and drug delivery mechanisms. The present study synthesized a functionalized nanocomposite (NC) containing graphene oxide (GO), chitosan (Ch), manganese (Mn), folic acid (FA), and brucine. The anticancer properties of the synthesized GO/Mn/Ch/FA-Brucine NCs were evaluated against liver cancer cells. GO/Mn/Ch/FA-Brucine NCs were characterized using several characterization techniques. The growth of HepG2 and Hep3B cells was analyzed using the methylthiazolyldiphenyl-tetrazolium bromide assay. The cell apoptosis was examined through dual staining. The levels of inflammatory and oxidative stress biomarkers were measured using the corresponding assay kits. Various characterization assays revealed the formation of crystalline GO/Mn/Ch/FA-Brucine NCs with tetragonal and agglomerated morphologies, various stretching and bonding, and an average particle size of 136.20 nm. GO/Mn/Ch/FA-Brucine NCs have effectively inhibited the viabilities of HepG2 and Hep3B cells. The NCs increased thiobarbituric acid reactive substances and reduced antioxidants and inflammatory mediators, thereby promoting apoptotic cell death in HepG2 cells. Our findings indicate that GO/Mn/Ch/FA-Brucine NCs can inhibit viability and promote apoptosis in liver cancer HepG2 cells.
DE GRUYTER POLAND SP Z O O
2191-9542
2191-9550
2024
13
1
10.1515/gps-2023-0184
Chemistry; Science & Technology - Other Topics; Engineering
gold
WOS:001262637800001
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001262637800001
title Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
title_short Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
title_full Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
title_fullStr Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
title_full_unstemmed Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
title_sort Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
container_title GREEN PROCESSING AND SYNTHESIS
language English
format Article
description Nanomedicine is the application of nanomaterials and nanotechnology to the development of novel pharmaceuticals and drug delivery mechanisms. The present study synthesized a functionalized nanocomposite (NC) containing graphene oxide (GO), chitosan (Ch), manganese (Mn), folic acid (FA), and brucine. The anticancer properties of the synthesized GO/Mn/Ch/FA-Brucine NCs were evaluated against liver cancer cells. GO/Mn/Ch/FA-Brucine NCs were characterized using several characterization techniques. The growth of HepG2 and Hep3B cells was analyzed using the methylthiazolyldiphenyl-tetrazolium bromide assay. The cell apoptosis was examined through dual staining. The levels of inflammatory and oxidative stress biomarkers were measured using the corresponding assay kits. Various characterization assays revealed the formation of crystalline GO/Mn/Ch/FA-Brucine NCs with tetragonal and agglomerated morphologies, various stretching and bonding, and an average particle size of 136.20 nm. GO/Mn/Ch/FA-Brucine NCs have effectively inhibited the viabilities of HepG2 and Hep3B cells. The NCs increased thiobarbituric acid reactive substances and reduced antioxidants and inflammatory mediators, thereby promoting apoptotic cell death in HepG2 cells. Our findings indicate that GO/Mn/Ch/FA-Brucine NCs can inhibit viability and promote apoptosis in liver cancer HepG2 cells.
publisher DE GRUYTER POLAND SP Z O O
issn 2191-9542
2191-9550
publishDate 2024
container_volume 13
container_issue 1
doi_str_mv 10.1515/gps-2023-0184
topic Chemistry; Science & Technology - Other Topics; Engineering
topic_facet Chemistry; Science & Technology - Other Topics; Engineering
accesstype gold
id WOS:001262637800001
url https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001262637800001
record_format wos
collection Web of Science (WoS)
_version_ 1809679210540695552