4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity

• Published in: NATURAL PRODUCT RESEARCH
• Main Authors: Tanjung, Mulyadi; Aldin, Muhammad Fajar; Arif, Noviani Nurma; Saputri, Ratih Dewi; Ahmat, Norizan; Tjahjandarie, Tjitjik Srie
• Format: Article; Early Access
• Language: English
• Published: TAYLOR & FRANCIS LTD 2024
• Subjects: Chemistry; Pharmacology & Pharmacy
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001230658100001

Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined with high-resolution ESIMS data. Compounds 1-4 were assayed to MCF-7 and HeLa cells for their cytotoxic activity. Mesulepidotin A (1) showed high activity with an IC50 value of 1.59 and 1.41 mu M, respectively. [GRAPHICS] .