4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined wit...
| Published in: | NATURAL PRODUCT RESEARCH |
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| Main Authors: | , , , , , , |
| Format: | Article; Early Access |
| Language: | English |
| Published: |
TAYLOR & FRANCIS LTD
2024
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| Subjects: | |
| Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001230658100001 |
| Summary: | Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined with high-resolution ESIMS data. Compounds 1-4 were assayed to MCF-7 and HeLa cells for their cytotoxic activity. Mesulepidotin A (1) showed high activity with an IC50 value of 1.59 and 1.41 mu M, respectively. [GRAPHICS] . |
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| ISSN: | 1478-6419 1478-6427 |
| DOI: | 10.1080/14786419.2024.2358526 |