Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies

By using a convergent methodology, a unique series of N-arylated 4-yl-benzamides containing a bi-heterocyclic thiazole-triazole core was synthesized and the structures of these hybrid molecules, 9a-k, were corroborated through spectral analyses. The in vitro studies of these multi-functional molecul...

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Published in:RSC ADVANCES
Main Authors: Khan, Farhan Mahmood; Abbasi, Muhammad Athar; Rehman, Aziz-ur; Siddiqui, Sabahat Zahra; Butt, Abdul Rehman Sadiq; Raza, Hussain; Hassan, Mubashir; Shah, Syed Adnan Ali; Shahid, Muhammad; Kim, Song Ja
Format: Article
Language:English
Published: ROYAL SOC CHEMISTRY 2024
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Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001229396900001