Soulaxanthone, a new xanthone derivative from Calophyllum soulattri

• Published in: NATURAL PRODUCT RESEARCH
• Main Authors: Heilman, Dayang Nurul Anisa Abang; Zamakshshari, Nor Hisam; Mian, Vivien Jong Yi; Hui, Audrey Yong Chee; Lizazman, Mas Atikah; Ahmad, Fasihuddin Badruddin
• Format: Article; Early Access
• Language: English
• Published: TAYLOR & FRANCIS LTD 2024
• Subjects: Chemistry; Pharmacology & Pharmacy
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001209228300001

In search for new metabolites from the stem bark of Calophyllum soulattri and Calophyllum gracilentum, led to the isolation of a new xanthone, soulaxanthone (1), along with four other known metabolites, euxanthone (2), calopolyanolide E (3), calanolide E (4) and friedelin (5). The structures of these compounds were identified and elucidated using spectroscopic techniques such as 1H NMR,13C NMR, COSY, DEPT, HSQC, HMBC, MS and FTIR. The antibacterial activities of compounds 1-5, as well as the extracts, were tested against five bacterial strains. Soulaxanthone (1) exhibited moderate activity against Pseudomonas aeruginosa with an MIC value of 25 mu g/mL. Hexane (non-polar) extract from both plants exhibited moderate activity against Enterobacter cloacae (MIC = 250 mu g/mL). Calopolyanolide E (3) and friedelin (5) showed bactericidal activity against Enterobacter cloacae (MBC = 50 mu g/mL), thus the compounds have the potential to serve as a new lead for developing effective antibacterial medication. [GRAPHICS] .