Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb

• Published in: NATURAL PRODUCT RESEARCH
• Main Authors: Salihu, Abubakar Siddiq; Salleh, Wan Mohd Nuzul Hakimi Wan; Barker, David; Arzmi, Mohd Hafiz; Ab Ghani, Nurunajah; Rasol, Nurulfazlina Edayah
• Format: Article; Early Access
• Language: English
• Published: TAYLOR & FRANCIS LTD 2024
• Subjects: Chemistry; Pharmacology & Pharmacy
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001208037000001

Phytochemical investigation of the leaves of Knema intermedia has led to the isolation of a new furofuran lignan, intermedianin 1 together with five known lignans, alpha-cubebin 2, beta-cubebin 3, bicubebin A 4, bicubebin B 5, and bicubebin C 6. The characterisation and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. The antifungal activity was tested using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. Compound 1 exhibited activity against C. albicans, C. lusitanae, and C. auris, (each with MIC/MFC value 250 mu g/mL) and increased the biofilm of C. auris (64.07 +/- 3.83%) and Candida lusitanae (62.90 +/- 3.41%) when treated with 500 mu g/mL.