Exploring the synthesis, molecular structure and biological activities of novel Bis-Schiff base derivatives: A combined theoretical and experimental approach

QR Code

Exploring the synthesis, molecular structure and biological activities of novel Bis-Schiff base derivatives: A combined theoretical and experimental approach

A library of six novel bis-Schiff base derivatives (2a -f) were synthesized, characterized through modern spectroscopic techniques and screened for their alpha-glucosidase and alpha-amylase inhibitory activities (in vitro). In the series, compound 2a (IC50 = 5.64 +/- 2.22 mu M) and 2f (IC50 = 22.78...

Full description

Bibliographic Details
Published in:	JOURNAL OF MOLECULAR STRUCTURE
Main Authors:	Gul, Sana; Alam, Aftab; Zainab; Mohammad, Assad; Elhenawy, Ahmed A.; Islam, Mohammad Shahidul; Shah, Syed Adnan Ali; Parveen, Zahida; Shah, Tanzeela Ahmad; Ahmad, Manzoor
Format:	Article
Language:	English
Published:	ELSEVIER 2024
Subjects:	Chemistry
Online Access:	https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001207472700001

Similar Items

Exploring the synthesis, molecular structure and biological activities of novel Bis-Schiff base derivatives: A combined theoretical and experimental approach
by: Gul S.; Alam A.; Zainab; Assad M.; Elhenawy A.A.; Islam M.S.; Shah S.A.A.; Parveen Z.; Shah T.A.; Ahmad M.
Published: (2024)

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach
by: Ullah, et al.
Published: (2024)

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach
by: Ullah, et al.
Published: (2024)

Experimental and computational profiling of novel bis-Schiff base derivatives bearing α-naphthalene moiety as potential tyrosinase inhibitors
by: Shah T.A.; Alam A.; Zainab; Khan M.; Elhenawy A.A.; Ayaz M.; Ali M.; Latif A.; Shah S.A.A.; Ahmad M.
Published: (2025)

Synthesis, characterization, enzyme inhibition and molecular docking studies of benzothiazole derivatives bearing alkyl phenyl ether fragments
by: Usman, et al.
Published: (2025)

Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights
by: Ur Rahman S.; Alam A.; Parveen Z.; Zainab; Assad M.; Adnan Ali Shah S.; Rafiq H.; Ayaz M.; Latif A.; Naveed Umar M.; Ali M.; Ahmad M.
Published: (2024)

Novel hydrazone schiff’s base derivatives of polyhydroquinoline: synthesis, in vitro prolyl oligopeptidase inhibitory activity and their Molecular docking study
by: Talab F.; Alam A.; Zainab; Ullah S.; Elhenawy A.A.; Shah S.A.A.; Ali M.; Halim S.A.; Khan A.; Latif A.; Al-Harrasi A.; Ahmad M.
Published: (2024)

Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach
by: Alam A.; Zainab; Elhenawy A.A.; Ur Rehman N.; Shahidul Islam M.; Dahlous K.A.; Talab F.; Shah S.A.A.; Ali M.; Ahmad M.
Published: (2024)

Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights
by: Alam A.; Gul S.; Zainab; Khan M.; Elhenawy A.A.; Islam M.S.; Ali M.; Ali Shah S.A.; Latif A.; Ahmad M.
Published: (2024)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
by: Kumar S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Selvaraj M.; Narasimhan B.
Published: (2017)

Synthesis, in vitro thymidine phosphorylase inhibitory activity and molecular docking study of novel pyridine-derived bis-oxadiazole bearing bis-schiff base derivatives
by: Hussain R.; Rehman W.; Rahim F.; Khan S.; Alanazi A.S.; Alanazi M.M.; Rasheed L.; Khan Y.; Adnan. Ali. Shah S.; Taha M.
Published: (2023)

Synthesis and antiurease & antioxidant activities of bis-Schiff bases of isophthalaldehyde
by: Rahim F.; Waseeq-Ur-Rehamn; Shehzad M.; Khan A.; Taha M.; Abid O.U.R.; Quereshi M.T.; Tauseef I.; Rehman W.
Published: (2016)

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach
by: Ullah N.; Alam A.; Zainab; Elhenawy A.A.; Naz S.; Islam M.S.; Ahmad S.; Shah S.A.A.; Ahmad M.
Published: (2024)

Bis(indolyl)methanes synthesis through sodium iodate and sodium hydrogen sulfite in water
by: Khan K.M.; Rahim F.; Shah S.A.A.; Taha M.; Ismail N.H.; Manzoor M.; Miana G.A.; Perveen S.
Published: (2015)

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
by: Rahim F.; Zaman K.; Taha M.; Ullah H.; Ghufran M.; Wadood A.; Rehman W.; Uddin N.; Shah S.A.A.; Sajid M.; Nawaz F.; Khan K.M.
Published: (2020)

Structural characterization, theoretical and antibacterial study of a V-shaped, cyclohexane bridged ONNO Schiff base
by: Nasaruddin N.H.; Ahmad S.N.; Sirat S.S.; Tan K.W.; Zakaria N.A.; Kurniawan C.; Bahron H.
Published: (2022)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood N.; Hussain R.; Khan S.; Rahim F.; Mumtaz S.; Taha M.; Ur Rahman Abid O.; Iqbal T.; Adnan Ali Shah S.; Omar Al Wesabi E.; Magam S.M.
Published: (2024)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood, et al.
Published: (2024)

Anti-cancer potential of benzophenone-bis-Schiff bases on human pancreatic cancer cell line
by: Khan K.M.; Rasheed H.; Fatima B.; Hayat M.; Rahim F.; Ullah H.; Hameed A.; Taha M.; Tahir A.; Perveen S.
Published: (2016)

Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents
by: Taha M.; Sain A.A.; Ali M.; Anouar E.H.; Rahim F.; Ismail N.H.; Adenan M.I.; Imran S.; Al-Harrasi A.; Nawaz F.; Iqbal N.; Khan K.M.
Published: (2020)

Synthesis, in vitro biological screening and docking study of benzo[d]oxazole bis Schiff base derivatives as a potent anti-Alzheimer agent
by: Taha M.; Rahim F.; Zaman K.; Anouar E.H.; Uddin N.; Nawaz F.; Sajid M.; Khan K.M.; Shah A.A.; Wadood A.; Rehman A.U.; Alhibshi A.H.
Published: (2023)

Synthesis, characterization, enzyme inhibition and molecular docking studies of benzothiazole derivatives bearing alkyl phenyl ether fragments
by: Usman M.; Alam A.; Zainab; Khan M.; Elhenawy A.A.; Ayaz M.; Alanazi M.M.; Latif A.; Shah S.A.A.; Ali M.; Ahmad M.
Published: (2025)

Assessing Fatigue Life Cycles of Material X10CrMoVNb9-1 through a Combination of Experimental and Finite Element Analysis
by: Rahim, et al.
Published: (2023)

Experimental theoretical studies on extract of date palm seed as a green anti-corrosion agent in hydrochloric acid solution
by: Mohammed N.J.; Othman N.K.; Taib M.F.M.; Samat M.H.; Yahya S.
Published: (2021)

Crystal structure of 2,2'-(((2,2-dimethylpropane-1,3-diyl)bis(azanylylidene))- bis(methanylylidene))bis(4-methoxyphenol)palladium(II)
by: Ahmad S.N.; Bahron H.; Tajuddin A.M.; Sukeri M.M.Y.
Published: (2017)

Bis-pyrimidine acetamides: Design, synthesis and biological evaluation
by: Kumar S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Narasimhan B.
Published: (2017)

Environmentally conscience corrosion inhibitors for mild steel in corrosive hydrochloric acid solution by Uncaria Cordata extract: experimental and theoretical studies
by: Othman N.A.; Ali A.M.M.; Samsi N.S.; Salim F.; Panuh D.; Yaakob M.K.; Embong Z.; Md Sauri A.S.; Che Isa N.N.; Nor Hashim N.Z.
Published: (2023)

Theoretical Aspects of XLPE-Based Blends and Nanocomposites
by: Thomas M.E.; Vidya R.; Thomas J.; Ahmad Z.
Published: (2021)

New acetylcholinesterase inhibitors isolated from Delphinium uncinatum
by: Gul N.; Ahmad S.; Ahmad H.; Aziz A.; Almehmadi M.; Amer Alsaiari A.; Allahyani M.; Zainab; Adnan Ali Shah S.; Ur Rahman N.; Ahmad M.
Published: (2023)

Experimental and theoretical study of thermoelectric generator waste heat recovery model for an ultra-low temperature PEM fuel cell powered vehicle
by: Saufi Sulaiman M.; Singh B.; Mohamed W.A.N.W.
Published: (2019)

Discovering the DPPH Free Radical Scavenging Activity of Azine Derivatives Bearing Ethyl Phenyl Ketone Moiety
by: Rehman, et al.
Published: (2024)

Microextraction experimental and forcefield theoretical modelling study on exploring a silica-enriched oil palm frond biomass for the determination of polycyclic aromatic hydrocarbons in Psidium guajava
by: Zainal Abidin N.H.; Wan Ibrahim W.N.; Raharjo Y.; Rashidi Nodeh H.; Abdul Wahab R.; Yaakob M.K.; Yahaya N.; Kamaruzaman S.; Mat Hadzir N.; Mohamad Hanapi N.S.
Published: (2024)

Microextraction experimental and forcefield theoretical modelling study on exploring a silica-enriched oil palm frond biomass for the determination of polycyclic aromatic hydrocarbons in Psidium guajava
by: Abidin, et al.
Published: (2024)

Assessing Fatigue Life Cycles of Material X10CrMoVNb9-1 through a Combination of Experimental and Finite Element Analysis
by: Rahim M.R.B.A.; Schmauder S.; Manurung Y.H.P.; Binkele P.; Dusza J.; Csanádi T.; Ahmad M.I.M.; Mat M.F.; Dogahe K.J.
Published: (2023)

INTERACTIONS OF UREASE WITH FLAVONE: A THEORETICAL PERSPECTIVE
by: Yaakob M.H.; Ang L.S.; Nizam S.H.S.; Fauzi S.S.M.; Shuhaime N.
Published: (2023)

Experimental investigation of combined heat recovery and power generation using a heat pipe assisted thermoelectric generator system
by: Remeli M.F.; Date A.; Orr B.; Ding L.C.; Singh B.; Affandi N.D.N.; Akbarzadeh A.
Published: (2016)

Experimental investigation on box-up cold-formed steel columns in fire
by: Muftah F.; Sani M.S.H.M.; Osman A.R.; Mohammad S.; Ngian S.P.
Published: (2018)

Synthesis and Molecular Docking of New Bis-Thiazolidinone-Based Chalcone Analogs as Effective Inhibitors of Acetylcholinesterase and Butyrylcholinesterase
by: Hussain R.; Rahim F.; Rehman W.; Taha M.; Khan S.; Zaman K.; Adnan Ali Shah S.; Wadood A.; Imran S.; Abdellatif M.H.
Published: (2022)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar, et al.
Published: (2024)

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives
by: Kumar S.; Singh J.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2018)