Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia

This study intended to explore the neuropsychological ramifications in childhood acute lymphoblastic leukemia (ALL) survivors in Malaysia and to examine treatment-related sequelae. A case-control study was conducted over a 2-year period. Seventy-one survivors of childhood ALL who had completed treat...

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Published in:SCIENTIFIC REPORTS
Main Authors: Alias, Hamidah; Ranai, Norashikin Mohd; Lau, Sie Chong Doris; de Sonneville, Leo M. J.
Format: Article
Language:English
Published: NATURE PORTFOLIO 2024
Subjects:
Online Access:https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001197575500035
author Alias
Hamidah; Ranai
Norashikin Mohd; Lau
Sie Chong Doris; de Sonneville
Leo M. J.
spellingShingle Alias
Hamidah; Ranai
Norashikin Mohd; Lau
Sie Chong Doris; de Sonneville
Leo M. J.
Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
Science & Technology - Other Topics
author_facet Alias
Hamidah; Ranai
Norashikin Mohd; Lau
Sie Chong Doris; de Sonneville
Leo M. J.
author_sort Alias
spelling Alias, Hamidah; Ranai, Norashikin Mohd; Lau, Sie Chong Doris; de Sonneville, Leo M. J.
Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
SCIENTIFIC REPORTS
English
Article
This study intended to explore the neuropsychological ramifications in childhood acute lymphoblastic leukemia (ALL) survivors in Malaysia and to examine treatment-related sequelae. A case-control study was conducted over a 2-year period. Seventy-one survivors of childhood ALL who had completed treatment for a minimum of 1 year and were in remission, and 71 healthy volunteers were enlisted. To assess alertness (processing speed) and essential executive functioning skills such as working memory capacity, inhibition, cognitive flexibility, and sustained attention, seven measures from the Amsterdam Neuropsychological Tasks (ANT) program were chosen. Main outcome measures were speed, stability and accuracy of responses. Mean age at diagnosis was 4.50 years (SD +/- 2.40) while mean age at study entry was 12.18 years (SD +/- 3.14). Survivors of childhood ALL underperformed on 6 out of 7 ANT tasks, indicating poorer sustained attention, working memory capacity, executive visuomotor control, and cognitive flexibility. Duration of treatment, age at diagnosis, gender, and cumulative doses of chemotherapy were not found to correlate with any of the neuropsychological outcome measures. Childhood ALL survivors in our center demonstrated significantly poorer neuropsychological status compared to healthy controls.
NATURE PORTFOLIO
2045-2322

2024
14
1
10.1038/s41598-024-58128-1
Science & Technology - Other Topics
gold
WOS:001197575500035
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001197575500035
title Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
title_short Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
title_full Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
title_fullStr Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
title_full_unstemmed Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
title_sort Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
container_title SCIENTIFIC REPORTS
language English
format Article
description This study intended to explore the neuropsychological ramifications in childhood acute lymphoblastic leukemia (ALL) survivors in Malaysia and to examine treatment-related sequelae. A case-control study was conducted over a 2-year period. Seventy-one survivors of childhood ALL who had completed treatment for a minimum of 1 year and were in remission, and 71 healthy volunteers were enlisted. To assess alertness (processing speed) and essential executive functioning skills such as working memory capacity, inhibition, cognitive flexibility, and sustained attention, seven measures from the Amsterdam Neuropsychological Tasks (ANT) program were chosen. Main outcome measures were speed, stability and accuracy of responses. Mean age at diagnosis was 4.50 years (SD +/- 2.40) while mean age at study entry was 12.18 years (SD +/- 3.14). Survivors of childhood ALL underperformed on 6 out of 7 ANT tasks, indicating poorer sustained attention, working memory capacity, executive visuomotor control, and cognitive flexibility. Duration of treatment, age at diagnosis, gender, and cumulative doses of chemotherapy were not found to correlate with any of the neuropsychological outcome measures. Childhood ALL survivors in our center demonstrated significantly poorer neuropsychological status compared to healthy controls.
publisher NATURE PORTFOLIO
issn 2045-2322

publishDate 2024
container_volume 14
container_issue 1
doi_str_mv 10.1038/s41598-024-58128-1
topic Science & Technology - Other Topics
topic_facet Science & Technology - Other Topics
accesstype gold
id WOS:001197575500035
url https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001197575500035
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