Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors

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Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors

Urease, a nickel-dependent enzyme found in various life forms, catalyzes urea breakdown, concluding nitrogen metabolism by generating ammonia and carbamate. This process causes a rise in pH, supports the survival of pathogens, and can lead to infections such as gastric disorders like ulcers and canc...

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Bibliographic Details
Published in:	FRONTIERS IN CHEMISTRY
Main Authors:	Akash, Muhammad; Zaib, Sumera; Ahmad, Matloob; Sultan, Sadia; Al-Hussain, Sami A.
Format:	Article
Language:	English
Published:	FRONTIERS MEDIA SA 2024
Subjects:	Chemistry
Online Access:	https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001191125900001

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