Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus
Background: Chronic administration of D -galactose and aluminium chloride (D-gal/AlCl3) has been associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Delta9-tetrahydrocannabinol (.6.9THC) is the key psychoactive constituent in Cannabis saliva and has shown promising mem...
Published in: | JOURNAL OF YOUNG PHARMACISTS |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
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INPHARM ASSOC, PHCOG NET
2024
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Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001180825900011 |
author |
Zakaria Fatin Nadzirah; Moklas Mohamad Aris Mohd; Baharuldin Mohamad Taufik Hidayat; Taib Che Norma Mat; Ab Hamid Hasiah; Hamid Hafizah Abdul; Chiroma Samaila Musa |
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spellingShingle |
Zakaria Fatin Nadzirah; Moklas Mohamad Aris Mohd; Baharuldin Mohamad Taufik Hidayat; Taib Che Norma Mat; Ab Hamid Hasiah; Hamid Hafizah Abdul; Chiroma Samaila Musa Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus Pharmacology & Pharmacy |
author_facet |
Zakaria Fatin Nadzirah; Moklas Mohamad Aris Mohd; Baharuldin Mohamad Taufik Hidayat; Taib Che Norma Mat; Ab Hamid Hasiah; Hamid Hafizah Abdul; Chiroma Samaila Musa |
author_sort |
Zakaria |
spelling |
Zakaria, Fatin Nadzirah; Moklas, Mohamad Aris Mohd; Baharuldin, Mohamad Taufik Hidayat; Taib, Che Norma Mat; Ab Hamid, Hasiah; Hamid, Hafizah Abdul; Chiroma, Samaila Musa Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus JOURNAL OF YOUNG PHARMACISTS English Article Background: Chronic administration of D -galactose and aluminium chloride (D-gal/AlCl3) has been associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Delta9-tetrahydrocannabinol (.6.9THC) is the key psychoactive constituent in Cannabis saliva and has shown promising memory -enhancing capability. This study evaluated the therapeutic effects of .6.9THC on D-gal/AlCl3-induced AD -like rat models through behavioural and histological analysis. Materials and Methods: Healthy male Wistar rats were subjected to AD induction by administering D -gal (60 mg/kg, intraperitoneal injection) and AlCl3 (200 mg/kg, oral) once daily for 10 consecutive weeks. Afterwards, .6.9THC (0.75 mg/kg, 1.5 mg/kg, and 3.0 mg/kg) were administered for 28 days as a treatment phase. Morris Water Maze (MWM) was employed to assess the rats' behaviour. The structural abnormalities in the hippocampus and neurogenesis markers were assessed. Results: Treatment with .6.9THC alleviated the cognitive dysfunction, as recorded from the MWM, and restored the morphological aberrations in the rat's hippocampus. Additionally, .6.9THC boosted neurogenesis by marked increased in GFAP+ cells, DCX+ cells, NeuN immunoreactivity and calbindin+ cells. Conclusion: In conclusion, .6.9THC ameliorates D -gal/ AlCl3-induced AD -like cognitive deficits in rat models, which could be linked to its ability to enhance neurogenesis. INPHARM ASSOC, PHCOG NET 0975-1483 0975-1505 2024 16 1 10.5530/jyp.2024.16.5 Pharmacology & Pharmacy gold WOS:001180825900011 https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001180825900011 |
title |
Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus |
title_short |
Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus |
title_full |
Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus |
title_fullStr |
Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus |
title_full_unstemmed |
Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus |
title_sort |
Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer's-Like Cognitive Deficit in Rats via Neurogenesis in their Hippocampus |
container_title |
JOURNAL OF YOUNG PHARMACISTS |
language |
English |
format |
Article |
description |
Background: Chronic administration of D -galactose and aluminium chloride (D-gal/AlCl3) has been associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Delta9-tetrahydrocannabinol (.6.9THC) is the key psychoactive constituent in Cannabis saliva and has shown promising memory -enhancing capability. This study evaluated the therapeutic effects of .6.9THC on D-gal/AlCl3-induced AD -like rat models through behavioural and histological analysis. Materials and Methods: Healthy male Wistar rats were subjected to AD induction by administering D -gal (60 mg/kg, intraperitoneal injection) and AlCl3 (200 mg/kg, oral) once daily for 10 consecutive weeks. Afterwards, .6.9THC (0.75 mg/kg, 1.5 mg/kg, and 3.0 mg/kg) were administered for 28 days as a treatment phase. Morris Water Maze (MWM) was employed to assess the rats' behaviour. The structural abnormalities in the hippocampus and neurogenesis markers were assessed. Results: Treatment with .6.9THC alleviated the cognitive dysfunction, as recorded from the MWM, and restored the morphological aberrations in the rat's hippocampus. Additionally, .6.9THC boosted neurogenesis by marked increased in GFAP+ cells, DCX+ cells, NeuN immunoreactivity and calbindin+ cells. Conclusion: In conclusion, .6.9THC ameliorates D -gal/ AlCl3-induced AD -like cognitive deficits in rat models, which could be linked to its ability to enhance neurogenesis. |
publisher |
INPHARM ASSOC, PHCOG NET |
issn |
0975-1483 0975-1505 |
publishDate |
2024 |
container_volume |
16 |
container_issue |
1 |
doi_str_mv |
10.5530/jyp.2024.16.5 |
topic |
Pharmacology & Pharmacy |
topic_facet |
Pharmacology & Pharmacy |
accesstype |
gold |
id |
WOS:001180825900011 |
url |
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001180825900011 |
record_format |
wos |
collection |
Web of Science (WoS) |
_version_ |
1809678907742355456 |