The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease
Coronary atherosclerosis is due to build-up of plaque within the coronary arteries. Post -mortem computed tomography (PMCT) allows non or minimally invasive visualization of abnormalities prior to an autopsy, however PMCT-angiography (PMCTA) greatly enhances relevant findings, especially in viewing...
Published in: | JOURNAL OF FORENSIC AND LEGAL MEDICINE |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Published: |
ELSEVIER SCI LTD
2024
|
Subjects: | |
Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001180067800001 |
author |
Woon Choy Ker; Omar Effat; Siew Sheue Feng; Nawawi Hapizah M.; Singh Mansharan Kaur Chainchel |
---|---|
spellingShingle |
Woon Choy Ker; Omar Effat; Siew Sheue Feng; Nawawi Hapizah M.; Singh Mansharan Kaur Chainchel The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease Legal Medicine |
author_facet |
Woon Choy Ker; Omar Effat; Siew Sheue Feng; Nawawi Hapizah M.; Singh Mansharan Kaur Chainchel |
author_sort |
Woon |
spelling |
Woon, Choy Ker; Omar, Effat; Siew, Sheue Feng; Nawawi, Hapizah M.; Singh, Mansharan Kaur Chainchel The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease JOURNAL OF FORENSIC AND LEGAL MEDICINE English Article Coronary atherosclerosis is due to build-up of plaque within the coronary arteries. Post -mortem computed tomography (PMCT) allows non or minimally invasive visualization of abnormalities prior to an autopsy, however PMCT-angiography (PMCTA) greatly enhances relevant findings, especially in viewing the cardiovascular system which is important in the diagnosis of coronary atherosclerosis. Contrast media used in PMCTA however has been reported to cause distortion of tissue which may interfere with post -mortem investigation outcomes. A cross sectional study to investigate the effect of PMCTA on tissue biomarkers in coronary arteries was performed involving cases brought in dead to the Institute and Accident and Emergency Unit. Sixty-three autopsy cases were included in this study, whereby 18 cases underwent PMCT while 45 cases underwent PMCTA. The subjects subsequently had a conventional autopsy where coronary artery sections were collected for standard histological examination and immunohistochemistry examination for endothelial inflammatory (CD36), prothrombogenic (TPA) and plaque stability (MMP-9) markers. The subjects consisted of 55 males and 8 females with a mean age +/- SD of 49 +/- 18.11 years. There were no significant differences in the coronary artery endothelial expression of CD36, MMP-9 and TPA between PMCT and PMCTA subjects. PMCTA does not alter CD36, TPA and MMP-9 markers supporting the safe use of PMCTA in post -mortem examinations. ELSEVIER SCI LTD 1752-928X 1532-2009 2024 102 10.1016/j.jflm.2024.102654 Legal Medicine WOS:001180067800001 https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001180067800001 |
title |
The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease |
title_short |
The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease |
title_full |
The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease |
title_fullStr |
The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease |
title_full_unstemmed |
The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease |
title_sort |
The effect of post-mortem computed tomography angiography (PMCTA) on biomarkers of coronary artery disease |
container_title |
JOURNAL OF FORENSIC AND LEGAL MEDICINE |
language |
English |
format |
Article |
description |
Coronary atherosclerosis is due to build-up of plaque within the coronary arteries. Post -mortem computed tomography (PMCT) allows non or minimally invasive visualization of abnormalities prior to an autopsy, however PMCT-angiography (PMCTA) greatly enhances relevant findings, especially in viewing the cardiovascular system which is important in the diagnosis of coronary atherosclerosis. Contrast media used in PMCTA however has been reported to cause distortion of tissue which may interfere with post -mortem investigation outcomes. A cross sectional study to investigate the effect of PMCTA on tissue biomarkers in coronary arteries was performed involving cases brought in dead to the Institute and Accident and Emergency Unit. Sixty-three autopsy cases were included in this study, whereby 18 cases underwent PMCT while 45 cases underwent PMCTA. The subjects subsequently had a conventional autopsy where coronary artery sections were collected for standard histological examination and immunohistochemistry examination for endothelial inflammatory (CD36), prothrombogenic (TPA) and plaque stability (MMP-9) markers. The subjects consisted of 55 males and 8 females with a mean age +/- SD of 49 +/- 18.11 years. There were no significant differences in the coronary artery endothelial expression of CD36, MMP-9 and TPA between PMCT and PMCTA subjects. PMCTA does not alter CD36, TPA and MMP-9 markers supporting the safe use of PMCTA in post -mortem examinations. |
publisher |
ELSEVIER SCI LTD |
issn |
1752-928X 1532-2009 |
publishDate |
2024 |
container_volume |
102 |
container_issue |
|
doi_str_mv |
10.1016/j.jflm.2024.102654 |
topic |
Legal Medicine |
topic_facet |
Legal Medicine |
accesstype |
|
id |
WOS:001180067800001 |
url |
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001180067800001 |
record_format |
wos |
collection |
Web of Science (WoS) |
_version_ |
1809678795695718400 |