Chemical Composition and Cytotoxicity of the Essential Oil of Rothmannia schoemannii Tirveng

• Published in: RIVISTA ITALIANA DELLE SOSTANZE GRASSE
• Main Authors: Salleh, Wan Mohd Nuzul Hakimi Wan; Salihu, Abubakar Siddiq; Ghani, Nurunajah Ab
• Format: Article
• Language: English
• Published: INNOVHUB SSI-AREA SSOG 2023
• Subjects: Food Science & Technology
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001171730100005

The chemical composition of the essential oil of Rothmannia schoemannii Tirveng. (Rubiaceae) was investigated for the first time. The essential oil was obtained by hydrodistillation and fully characterised by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). In total, 28 components were identified in the essential oil, which made up 99.6% of the total oil. The essential oil is composed mainly of beta-eudesmol (30.8%), a-cadinol (18.2%), caryophyllene oxide (6.5%), delta-cadinene (5.5%), and.- eudesmol (5.4%). The essential oil exhibited cytotoxic activity against J5 (human hepatocellular carcinoma) and A549 (human lung adenocarcinoma) cells with IC50 values of 112.5 and 98.5 ug/mL, respectively.