TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia

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TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia

Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagonists have been examined for their efficacy in miti...

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Bibliographic Details
Published in:	NEUROBIOLOGY OF DISEASE
Main Authors:	Poore, Charlene P.; Hazalin, Nurul A. M. N.; Wei, Shunhui; Low, See Wee; Chen, Bo; Nilius, Bernd; Hassan, Zurina; Liao, Ping
Format:	Article
Language:	English
Published:	ACADEMIC PRESS INC ELSEVIER SCIENCE 2024
Subjects:	Neurosciences & Neurology
Online Access:	https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001166358900001

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