OPTIMIZATION OF DEPROTEINIZATION METHODS, HPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTIFICATION OF 6Β- HYDROXYTESTOSTERONE IN CELL CULTURE MEDIA

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OPTIMIZATION OF DEPROTEINIZATION METHODS, HPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTIFICATION OF 6Β- HYDROXYTESTOSTERONE IN CELL CULTURE MEDIA

Testosterone is commonly used as a marker probe drug for CYP3A4 metabolic activity. Accurate measurement of its metabolite, 68-hydroxytestosterone in cell culture media is very crucial. This study aimed to optimize solvent extraction method as well as to develop and validate HPLC analytical method f...

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Bibliographic Details
Published in:	JURNAL TEKNOLOGI-SCIENCES & ENGINEERING
Main Authors:	Ridhwan, Mohamad Jemain Mohamad; Abd Mutalib, Nurliana; Abd Latip, Normala; Rasol, Nurulfazlina Edayah; Abu Bakar, Syahrul Imran; Ismail, Nor Hadiani
Format:	Article
Language:	English
Published:	PENERBIT UTM PRESS 2024
Subjects:	Engineering
Online Access:	https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001159078800002

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