The role of commonly used transition metals in total synthesis of indole alkaloids

• Published in: ARABIAN JOURNAL OF CHEMISTRY
• Main Authors: Khan, Abdul Hannan; Altaf, Sawaira; Rasool, Nasir; Mubarik, Adeel; Ahmad, Matloob; Shah, Syed Adnan Ali; Imran, Syahrul; Bajaber, Majed A.
• Format: Article; Early Access
• Language: English
• Published: ELSEVIER 2024
• Subjects: Chemistry
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001141018300001

This Paper reviews the most recent advances in synthesizing indole alkaloids using transition metal-catalyzed methods. The essential class of natural substances known as indole alkaloids has several biological effects, including anti-inflammatory, anti-cancer, and anti-bacterial properties. Although there are numerous known natural sources of indole alkaloids, due to their scarcity and complexity, total synthesis has emerged as a promising technique of manufacture. Transition metal-catalyzed methods have become efficient tools for synthesizing indole alkaloids due to their high selectivity and efficiency. The various metal-catalyzed reactions that are used to synthesize indole alkaloids are discussed in this paper, including cross-coupling, cycloaddition, and oxidative cyclization reactions in last five years.