The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats
Objectives and background: Vitamin D has been associated with an increased risk of tooth loss and the severity of periodontal diseases. This study aimed to evaluate the effect of vitamin D on the clinical, radiographic, and serum level changes of bone turnover biomarkers in ligature-induced periodon...
Published in: | SAUDI DENTAL JOURNAL |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
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2023
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Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001138831000001 |
author |
Zainal Muhammad Hilmi; Hidayat Faizal Hafez; Bayaty Fouad H. Al |
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Zainal Muhammad Hilmi; Hidayat Faizal Hafez; Bayaty Fouad H. Al The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats Dentistry, Oral Surgery & Medicine |
author_facet |
Zainal Muhammad Hilmi; Hidayat Faizal Hafez; Bayaty Fouad H. Al |
author_sort |
Zainal |
spelling |
Zainal, Muhammad Hilmi; Hidayat, Faizal Hafez; Bayaty, Fouad H. Al The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats SAUDI DENTAL JOURNAL English Article Objectives and background: Vitamin D has been associated with an increased risk of tooth loss and the severity of periodontal diseases. This study aimed to evaluate the effect of vitamin D on the clinical, radiographic, and serum level changes of bone turnover biomarkers in ligature-induced periodontitis.Methods: A total of 28 rats were included in this study and divided into test groups: Vitamin D supplement (VS), Vitamin D deficient (VD), and control (CG). Ligature-induced periodontal tissue destruction was performed and kept for 21 days. Clinical attachment and radiographic changes were recorded, and serum samples were tested for Osteoprotegerin (OPG), Dickkopf-1 (DKK1), Sclerostin (SOST), and Fibroblast growth factor 23 (FGF23) on the initial and final day of the study.Results: Groups that were made VD exhibited a more significant amount of clinical attachment loss (1.05 +/- 0.50 mm) compared to the CG (0.83 +/- 0.14 mm) and VS group (0.60 +/- 0.13 mm), showing significant differences (p < 0.05). The radiographic alveolar bone loss amount was greater in the VD group compared to the other groups. For serum level assessment, the VD groups also exhibited a statistically significant reduction in the levels of OPG. They showed higher concentrations of DKK1, SOST, and FGF23 than other groups, with significant differences (p < 0.05).Conclusion: The results revealed that Vitamin D may play a role in the progression of periodontal disease. It was found to affect both clinical parameters and bone turnover biomarkers, suggesting its potential impact on the disease process. ELSEVIER 1013-9052 1658-3558 2023 35 8 10.1016/j.sdentj.2023.07.020 Dentistry, Oral Surgery & Medicine gold, Green Published WOS:001138831000001 https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001138831000001 |
title |
The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats |
title_short |
The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats |
title_full |
The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats |
title_fullStr |
The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats |
title_full_unstemmed |
The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats |
title_sort |
The impact of vitamin D on clinical parameters and bone turnover biomarkers in ligature-induced periodontitis: An experimental study in rats |
container_title |
SAUDI DENTAL JOURNAL |
language |
English |
format |
Article |
description |
Objectives and background: Vitamin D has been associated with an increased risk of tooth loss and the severity of periodontal diseases. This study aimed to evaluate the effect of vitamin D on the clinical, radiographic, and serum level changes of bone turnover biomarkers in ligature-induced periodontitis.Methods: A total of 28 rats were included in this study and divided into test groups: Vitamin D supplement (VS), Vitamin D deficient (VD), and control (CG). Ligature-induced periodontal tissue destruction was performed and kept for 21 days. Clinical attachment and radiographic changes were recorded, and serum samples were tested for Osteoprotegerin (OPG), Dickkopf-1 (DKK1), Sclerostin (SOST), and Fibroblast growth factor 23 (FGF23) on the initial and final day of the study.Results: Groups that were made VD exhibited a more significant amount of clinical attachment loss (1.05 +/- 0.50 mm) compared to the CG (0.83 +/- 0.14 mm) and VS group (0.60 +/- 0.13 mm), showing significant differences (p < 0.05). The radiographic alveolar bone loss amount was greater in the VD group compared to the other groups. For serum level assessment, the VD groups also exhibited a statistically significant reduction in the levels of OPG. They showed higher concentrations of DKK1, SOST, and FGF23 than other groups, with significant differences (p < 0.05).Conclusion: The results revealed that Vitamin D may play a role in the progression of periodontal disease. It was found to affect both clinical parameters and bone turnover biomarkers, suggesting its potential impact on the disease process. |
publisher |
ELSEVIER |
issn |
1013-9052 1658-3558 |
publishDate |
2023 |
container_volume |
35 |
container_issue |
8 |
doi_str_mv |
10.1016/j.sdentj.2023.07.020 |
topic |
Dentistry, Oral Surgery & Medicine |
topic_facet |
Dentistry, Oral Surgery & Medicine |
accesstype |
gold, Green Published |
id |
WOS:001138831000001 |
url |
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001138831000001 |
record_format |
wos |
collection |
Web of Science (WoS) |
_version_ |
1809678576324182016 |