Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model
This study assessed the corrosion resistance, intracutaneous reactivity, acute systemic toxicity, and in situ tissue effect of the implantation of porous NiTi fabricated by metal injection molding in animal models. For the intracutaneous reactivity study, five intracutaneous injections were administ...
Published in: | ACS BIOMATERIALS SCIENCE & ENGINEERING |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
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AMER CHEMICAL SOC
2023
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Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001138342800001 |
author |
Mustafa Nor Wati Nur Atikah; Ahmad Rohana; Ahmad Khushaini Muhammad Asif; Kamar Affendi Nur Hafizah; Ab Ghani Siti Mariam; Tan Su Keng; Ismail Muhammad Hussain; Goo Chui Ling; Kassim Mohd Zulkifli; Lim Tong Wah; Teh Lay Kek |
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spellingShingle |
Mustafa Nor Wati Nur Atikah; Ahmad Rohana; Ahmad Khushaini Muhammad Asif; Kamar Affendi Nur Hafizah; Ab Ghani Siti Mariam; Tan Su Keng; Ismail Muhammad Hussain; Goo Chui Ling; Kassim Mohd Zulkifli; Lim Tong Wah; Teh Lay Kek Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model Materials Science |
author_facet |
Mustafa Nor Wati Nur Atikah; Ahmad Rohana; Ahmad Khushaini Muhammad Asif; Kamar Affendi Nur Hafizah; Ab Ghani Siti Mariam; Tan Su Keng; Ismail Muhammad Hussain; Goo Chui Ling; Kassim Mohd Zulkifli; Lim Tong Wah; Teh Lay Kek |
author_sort |
Mustafa |
spelling |
Mustafa, Nor Wati Nur Atikah; Ahmad, Rohana; Ahmad Khushaini, Muhammad Asif; Kamar Affendi, Nur Hafizah; Ab Ghani, Siti Mariam; Tan, Su Keng; Ismail, Muhammad Hussain; Goo, Chui Ling; Kassim, Mohd Zulkifli; Lim, Tong Wah; Teh, Lay Kek Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model ACS BIOMATERIALS SCIENCE & ENGINEERING English Article This study assessed the corrosion resistance, intracutaneous reactivity, acute systemic toxicity, and in situ tissue effect of the implantation of porous NiTi fabricated by metal injection molding in animal models. For the intracutaneous reactivity study, five intracutaneous injections were administered per site with and without the tested extract in polar and nonpolar solutions. The extract was also delivered via intravenous and intraperitoneal routes for acute systemic toxicity. TiAl6 V4 (control) and porous NiTi were implanted in rabbit femora for a period of 13 weeks to evaluate the in situ tissue response. Corrosion was evaluated through open and cyclic polarization in PBS, while biocompatibility was investigated by assessing the general conditions, skin irritation score (edema and erythema), and histopathology. No active dissolution or hysteresis loop was observed in the corrosion study. None of the animals exhibited death, moribundity, impending death, severe pain, self-mutilation, or overgrooming. No edema was observed at injection sites. Only the positive control showed an erythematous reaction at 24, 48, and 72 h observations (p < 0.001). Porous NiTi showed a low in situ biological response for inflammation, neovascularization, and fibrosis in comparison to the control implant (p = 0.247, 0.005, and 0.011, respectively). Porous NiTi also demonstrated high pitting corrosion resistance while causing no acute hypersensitivity or acute systemic toxicity. The study concludes that porous NiTi implants were unlikely to cause local sensitization, acute systemic toxicity, or chronic inflammatory reactions in an animal model. Porous NiTi also exhibited osseointegration equivalent to Ti6AI4 V of known biocompatibility. AMER CHEMICAL SOC 2373-9878 2023 10 1 10.1021/acsbiomaterials.3c01551 Materials Science WOS:001138342800001 https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001138342800001 |
title |
Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model |
title_short |
Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model |
title_full |
Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model |
title_fullStr |
Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model |
title_full_unstemmed |
Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model |
title_sort |
Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model |
container_title |
ACS BIOMATERIALS SCIENCE & ENGINEERING |
language |
English |
format |
Article |
description |
This study assessed the corrosion resistance, intracutaneous reactivity, acute systemic toxicity, and in situ tissue effect of the implantation of porous NiTi fabricated by metal injection molding in animal models. For the intracutaneous reactivity study, five intracutaneous injections were administered per site with and without the tested extract in polar and nonpolar solutions. The extract was also delivered via intravenous and intraperitoneal routes for acute systemic toxicity. TiAl6 V4 (control) and porous NiTi were implanted in rabbit femora for a period of 13 weeks to evaluate the in situ tissue response. Corrosion was evaluated through open and cyclic polarization in PBS, while biocompatibility was investigated by assessing the general conditions, skin irritation score (edema and erythema), and histopathology. No active dissolution or hysteresis loop was observed in the corrosion study. None of the animals exhibited death, moribundity, impending death, severe pain, self-mutilation, or overgrooming. No edema was observed at injection sites. Only the positive control showed an erythematous reaction at 24, 48, and 72 h observations (p < 0.001). Porous NiTi showed a low in situ biological response for inflammation, neovascularization, and fibrosis in comparison to the control implant (p = 0.247, 0.005, and 0.011, respectively). Porous NiTi also demonstrated high pitting corrosion resistance while causing no acute hypersensitivity or acute systemic toxicity. The study concludes that porous NiTi implants were unlikely to cause local sensitization, acute systemic toxicity, or chronic inflammatory reactions in an animal model. Porous NiTi also exhibited osseointegration equivalent to Ti6AI4 V of known biocompatibility. |
publisher |
AMER CHEMICAL SOC |
issn |
2373-9878 |
publishDate |
2023 |
container_volume |
10 |
container_issue |
1 |
doi_str_mv |
10.1021/acsbiomaterials.3c01551 |
topic |
Materials Science |
topic_facet |
Materials Science |
accesstype |
|
id |
WOS:001138342800001 |
url |
https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001138342800001 |
record_format |
wos |
collection |
Web of Science (WoS) |
_version_ |
1809678578930941952 |